PDF(Pubmed)
Abstract：
OBJECTIVE: To investigate the associations of physical activity (PA) and sedentary behaviour in early childhood with asthma and reduced lung function in later childhood within a large collaborative study.
METHODS: Pooling of longitudinal data from collaborating birth cohorts using meta-analysis of separate cohort-specific estimates and analysis of individual participant data of all cohorts combined.
METHODS: Children aged 0-18 years from 26 European birth cohorts.
METHODS: 136 071 individual children from 26 cohorts, with information on PA and/or sedentary behaviour in early childhood and asthma assessment in later childhood.
METHODS: Questionnaire-based current asthma and lung function measured by spirometry (forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity) at age 6-18 years.
RESULTS: Questionnaire-based and accelerometry-based PA and sedentary behaviour at age 3-5 years was not associated with asthma at age 6-18 years (PA in hours/day adjusted OR 1.01, 95% CI 0.98 to 1.04; sedentary behaviour in hours/day adjusted OR 1.03, 95% CI 0.99 to 1.07). PA was not associated with lung function at any age. Analyses of sedentary behaviour and lung function showed inconsistent results.
CONCLUSIONS: Reduced PA and increased sedentary behaviour before 6 years of age were not associated with the presence of asthma later in childhood.
METHODS: Pooling of longitudinal data from collaborating birth cohorts using meta-analysis of separate cohort-specific estimates and analysis of individual participant data of all cohorts combined.
METHODS: Children aged 0-18 years from 26 European birth cohorts.
METHODS: 136 071 individual children from 26 cohorts, with information on PA and/or sedentary behaviour in early childhood and asthma assessment in later childhood.
METHODS: Questionnaire-based current asthma and lung function measured by spirometry (forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity) at age 6-18 years.
RESULTS: Questionnaire-based and accelerometry-based PA and sedentary behaviour at age 3-5 years was not associated with asthma at age 6-18 years (PA in hours/day adjusted OR 1.01, 95% CI 0.98 to 1.04; sedentary behaviour in hours/day adjusted OR 1.03, 95% CI 0.99 to 1.07). PA was not associated with lung function at any age. Analyses of sedentary behaviour and lung function showed inconsistent results.
CONCLUSIONS: Reduced PA and increased sedentary behaviour before 6 years of age were not associated with the presence of asthma later in childhood.
摘要：
目的：在一项大型合作研究中，探讨儿童早期体力活动（PA）和久坐行为与哮喘和儿童后期肺功能降低的关系。
方法：汇集来自合作出生队列的纵向数据，使用单独的队列特异性估计的荟萃分析和所有队列的个体参与者数据的分析。
方法：来自26个欧洲出生队列的0-18岁儿童。
方法：来自26个队列的136071名儿童，提供有关儿童早期PA和/或久坐行为以及儿童后期哮喘评估的信息。
方法：通过肺活量测定法测量的基于问卷的当前哮喘和肺功能（1s的用力呼气量（FEV1），FEV1/强迫肺活量）6-18岁。
结果：3-5岁时的基于问卷和基于加速度测量的PA和久坐行为与6-18岁时的哮喘无关（PA以小时/天为单位调整OR1.01，95％CI0.98至1.04；以小时/天为单位的久坐行为调整OR1.03，95％CI0.99至1.07）。PA在任何年龄均与肺功能无关。对久坐行为和肺功能的分析显示结果不一致。
结论：6岁之前PA的降低和久坐行为的增加与儿童期后期哮喘的存在无关。
方法：汇集来自合作出生队列的纵向数据，使用单独的队列特异性估计的荟萃分析和所有队列的个体参与者数据的分析。
方法：来自26个欧洲出生队列的0-18岁儿童。
方法：来自26个队列的136071名儿童，提供有关儿童早期PA和/或久坐行为以及儿童后期哮喘评估的信息。
方法：通过肺活量测定法测量的基于问卷的当前哮喘和肺功能（1s的用力呼气量（FEV1），FEV1/强迫肺活量）6-18岁。
结果：3-5岁时的基于问卷和基于加速度测量的PA和久坐行为与6-18岁时的哮喘无关（PA以小时/天为单位调整OR1.01，95％CI0.98至1.04；以小时/天为单位的久坐行为调整OR1.03，95％CI0.99至1.07）。PA在任何年龄均与肺功能无关。对久坐行为和肺功能的分析显示结果不一致。
结论：6岁之前PA的降低和久坐行为的增加与儿童期后期哮喘的存在无关。
