心血管疾病仍然是全球范围内死亡的主要原因。具有心血管疾病危险因素的个体,如高血压(BP)和肥胖,面临经历器官特异性病理生理变化的风险增加。这种损害包括心脏和外周血管系统的病理生理变化,比如心室肥大,动脉硬化,血管狭窄和狭窄。因此,这些损害与发生包括卒中在内的严重心血管疾病的风险增加有关,心肌梗塞,心力衰竭,和冠心病。在所有与心血管疾病相关的危险因素中,高血压是最突出的。然而,传统的静息血压测量方法,如听诊或示波法,可能无法识别许多无症状的高血压个体。最近,运动血压已成为识别真实(高)血压水平和评估潜在心血管风险的有价值的诊断工具,除了成人静息血压测量。此外,众多既定因素,如低心肺健康和高身体脂肪,已被证实有助于运动血压和相关的心血管风险。修改这些因素可能有助于降低高运动血压,因此,减轻心血管疾病的负担。大量证据表明,晚年的心血管疾病起源于早年。患有这些心血管危险因素的儿童和青少年在以后的生活中也具有更大的患心血管疾病的倾向。然而,以前关于运动BP的临床效用的大多数研究都是在中老年人群进行的,通常与预先存在的临床条件。因此,有必要进一步研究影响青春期运动血压的因素及其与生命早期心血管风险的关系.我们先前发表的工作表明,运动BP是检测心血管风险增加的青少年的潜在有用方法。有心血管危险因素的儿童和青少年在以后的生活中更容易患上心血管疾病。然而,以前关于运动BP临床效用的研究主要集中在具有预先存在临床疾病的中老年人群.因此,有必要进一步研究影响青春期运动血压的因素及其与未来心血管风险的关系.我们之前的研究,专注于在次最大强度下测量的运动血压,已经表明,锻炼BP是识别心血管风险增加的青少年的潜在有用方法。我们先前的研究结果表明,改善心肺健康和减少身体脂肪可能有助于降低患心血管疾病的风险并改善整体心血管健康。这些发现对于制定有效的预防和早期发现策略具有重要意义,这有助于改善公共卫生结果。
Cardiovascular disease remains the leading cause of mortality on a global scale. Individuals who possess risk factors for cardiovascular disease, such as high blood pressure (BP) and obesity, face an elevated risk of experiencing organ-specific pathophysiological changes. This damage includes pathophysiological changes in the heart and peripheral vascular systems, such as ventricular hypertrophy, arterial stiffening, and vascular narrowing and stenosis. Consequently, these damages are associated with an increased risk of developing severe cardiovascular outcomes including stroke, myocardial infarction, heart failure, and coronary heart disease. Among all the risk factors associated with cardiovascular disease, high blood pressure emerges as the most prominent. However, conventional resting BP measurement methods such as auscultatory or oscillometric methods may fail to identify many individuals with asymptomatic high BP. Recently,
exercise BP has emerged as a valuable diagnostic tool for identifying real (high) blood pressure levels and assessing underlying cardiovascular risk, in addition to resting BP measurements in adults. Furthermore, numerous established factors, such as low cardiorespiratory fitness and high body fatness, have been confirmed to contribute to exercise BP and the associated cardiovascular risk. Modifying these factors may help reduce high exercise BP and, consequently, alleviate the burden of cardiovascular disease. A significant body of evidence has demonstrated cardiovascular disease in later life have their origins in early life. Children and adolescents with these cardiovascular risk factors also possess a greater propensity to develop cardiovascular diseases later in life. Nevertheless, the majority of previous studies on the clinical utility of exercise BP have been conducted in middle-to-older aged populations, often with pre-existing clinical conditions. Therefore, there is a need to investigate further of the factors influencing
exercise BP in adolescence and its association with cardiovascular risk in early life. Our previously published work showed that exercise BP is a potential useful method to detect adolescents with increased cardiovascular risk. Children and adolescents with cardiovascular risk factors are more likely to develop cardiovascular diseases later in life. However, previous studies on the clinical utility of exercise BP have largely focused on middle-to-older aged populations with pre-existing clinical conditions. Therefore, there is a need to investigate further the factors influencing
exercise BP in adolescence and its association with future cardiovascular risk. Our previous studies, which focused on
exercise BP measured at submaximal intensity, have shown that
exercise BP is a potentially useful method for identifying adolescents at increased cardiovascular risk. Our previous findings suggest that improving cardio-respiratory fitness and reducing body fatness may help to reduce the risk of developing cardiovascular disease and improve overall cardiovascular health. These findings have important implications for the development of effective prevention and early detection strategies, which can contribute to improved public health outcomes.