PDF(Pubmed)
Abstract：
The aim of this study was to evaluate the association between the Mediterranean diet (MD) and the accumulation of advanced glycation end products (AGEs) measured by skin autofluorescence. This cross-sectional study included 1016 healthy students from the University of Split, Croatia. Participants completed a self-administered questionnaire. Adherence to the MD was assessed using the Mediterranean Diet Serving Score (MDSS), and tissue AGEs accumulation was measured using the AGE Reader mu (DiagnOptics). Multivariate linear regression was used in the analysis. Students\' age and female gender were associated with higher levels of AGEs, which was likewise found for greater coffee intake, adequate olive oil consumption, smoking, and lower levels of physical activity. Higher consummation of vegetables and eating breakfast regularly were associated with lower AGEs levels. The overall MD adherence was not associated with AGEs, possibly due to very low overall compliance to the MD principles among students (8.3% in women and 3.8% in men). Health perception was positively associated with the MD and nonsmoking and negatively with the perceived stress level, while AGEs did not show significant association with self-rated students\' health. These results indicate that various lifestyle habits are associated with AGEs accumulation even in young and generally healthy people. Hence, health promotion and preventive measures are necessary from an early age.
摘要：
这项研究的目的是评估地中海饮食（MD）与通过皮肤自发荧光测量的晚期糖基化终产物（AGEs）积累之间的关联。这项横断面研究包括来自斯普利特大学的1016名健康学生，克罗地亚。参与者完成了一份自我管理的问卷。使用地中海饮食服务评分（MDSS）评估对MD的依从性，和组织AGEs积累使用AGE阅读器mu(诊断光学)测量。分析采用多元线性回归。学生的年龄和女性性别与较高的AGEs水平相关，这同样被发现有更多的咖啡摄入量，充足的橄榄油消费，吸烟,和较低水平的体力活动。较高的蔬菜消耗和定期吃早餐与较低的AGEs水平有关。总体MD依从性与AGEs无关，可能是由于学生对MD原则的总体依从性非常低（女性为8.3％，男性为3.8％）。健康感知与MD和不吸烟呈正相关，与感知的压力水平呈负相关。而AGEs与自评学生的健康状况没有显着关联。这些结果表明，即使在年轻人和一般健康人中，各种生活习惯也与AGEs积累有关。因此，从小就有必要采取健康促进和预防措施。
