Abstract：
Substance Use Disorder (SUD) represents one of the most frequent conditions worldwide which commonly coexists with major depressive disorder (MDD). This comorbidity (SUD + MDD) is one of the most prevalent with patients showing certain social and clinical characteristics that could lead to a worsening of their cognitive performance. However, despite these particularities, only a few studies have addressed the possible differences in cognitive performance between patients with SUD + MDD compared with those with SUD-only patients. Therefore, the aim of this study is to examine the clinical and cognitive profile of patients with SUD + MDD vs. SUD-only who are in early remission phase. For this purpose, 271 male patients underwent a clinical and neuropsychological assessment (SUD + MDD group: N = 101; SUD-only group: N = 170). Results indicated that SUD + MDD patients showed worse cognitive performance than SUD in visuospatial reasoning, verbal memory and learning, recognition, and processing speed even after a 3-month period of abstinence. Furthermore, these patients exhibited more self-reported prefrontal symptoms, as well as worse social and clinical conditions. This study indicates that the neurocognitive and clinical profile of patients with SUD + MDD could represent a risk since their characteristics have been associated with poorer recovery and prognosis. Our results could be helpful in clinical practice highlighting the need for cognitive remediation strategies in these populations, providing information that would allow the implementation of more appropriate treatments and preventive strategies.
摘要：
物质使用障碍（SUD）是全球最常见的疾病之一，通常与重度抑郁症（MDD）并存。这种合并症(SUD+MDD)是表现出某些可能导致其认知表现恶化的社会和临床特征的患者中最普遍的疾病之一。然而,尽管有这些特殊性,只有少数研究解决了SUD+MDD患者与仅SUD患者相比在认知表现方面的可能差异.因此,这项研究的目的是检查SUD+MDD患者的临床和认知概况只有处于早期缓解期的SUD。为此,271名男性患者接受了临床和神经心理学评估（SUDMDD组：N=101；仅SUD组：N=170）。结果表明，SUD+MDD患者在视觉空间推理方面表现出比SUD更差的认知表现，言语记忆和学习，认可,和处理速度，即使经过3个月的禁欲期。此外，这些患者表现出更多自我报告的前额叶症状，以及更糟糕的社会和临床状况。这项研究表明，SUD+MDD患者的神经认知和临床特征可能代表一种风险，因为他们的特征与较差的恢复和预后相关。我们的结果可能有助于临床实践，强调在这些人群中需要认知修复策略，提供信息，以便实施更适当的治疗和预防策略。
