■丙型肝炎病毒(HCV)感染率的增加归因于物质使用流行。目前关于并行HCV流行率的数据有限。
■评估西弗吉尼亚州(WV)孕妇HCV感染的患病率并确定影响因素。
■对2020年01月至2024年01月30日期间在WV分娩的所有孕妇进行的基于人群的回顾性队列研究(N=69,925)。使用多个对数二项回归模型来估计调整风险比(ARR)和95%置信区间(CI)。
■母体HCV感染率为每1000分娩38例。患有HCV的怀孕个体的平均年龄为29.99(SD4.95)。HCV的风险在白人和白人中明显更高。少数族裔群体[ARR1.93(1.50,2.49)],低于[ARR1.57(1.37,1.79)]或至少高中[ARR1.31(1.17,1.47)]的人不仅仅是高中教育,医疗补助[ARR2.32(1.99,2.71)]vs.私人医疗保险,居住在小型地铁[ARR1.32(1.17,1.48)]和中型地铁[ARR1.41(1.24,1.61)]的人,vs.农村地区,和吸烟的人[ARR3.51(3.10,3.97)]。使用阿片类药物的患者的HCV风险最高[ARR4.43(3.95,4.96)];其次是兴奋剂使用[ARR=1.79(1.57,2.04)]。
■我们的研究结果强调,产妇年龄,种族,教育,和健康保险类型与孕产妇HCV感染有关。在WV怀孕期间吸烟和使用阿片类药物和兴奋剂的怀孕个体的关联程度最高。
UNASSIGNED: The increasing rate of Hepatitis C virus (HCV) infection has been attributed to the substance use epidemic. There is limited data on the current rates of the paralleling HCV epidemic.
UNASSIGNED: To estimate the prevalence of maternal HCV infection in West Virginia (WV) and identify contributing factors.
UNASSIGNED: Population-based retrospective cohort study of all pregnant individual(s) who gave birth in WV between 01/01/2020 to 01/30/2024 (N = 69,925). Multiple log-binomial regression models were used to estimate the adjusted risk ratio (ARR) and the 95% confidence intervals (CI).
UNASSIGNED: The rate of maternal HCV infection was 38 per 1,000 deliveries. The mean age of pregnant individual(s) with HCV was 29.99 (SD 4.95). The risk of HCV was significantly higher in White vs. minority racial groups [ARR 1.93 (1.50, 2.49)], those with less than [ARR 1.57 (1.37, 1.79)] or at least high school [ARR 1.31 (1.17, 1.47)] vs. more than high school education, those on Medicaid [ARR 2.32 (1.99, 2.71)] vs. private health insurance, those residing in small-metro [ARR 1.32 (1.17, 1.48)] and medium-metro [ARR 1.41 (1.24, 1.61)], vs. rural areas, and those who smoked [ARR 3.51 (3.10, 3.97)]. HCV risk was highest for those using opioids [ARR 4.43 (3.95, 4.96)]; followed by stimulant use [ARR = 1.79 (1.57, 2.04)].
UNASSIGNED: Our findings highlight that maternal age, race, education, and type of health insurance are associated with maternal HCV infection. The magnitude of association was highest for pregnant individual(s) who smoked and used opioids and stimulants during pregnancy in WV.