■重度抑郁症(MDDs)给个人和社会带来了沉重负担;然而,其长期趋势仍需要进一步详细分析。
■本研究旨在分析过去三十年中国居民MDD发病率的性别时间趋势和队列变化。
■利用年龄-时期-队列-相互作用模型并利用2019年全球疾病负担研究的数据,这项研究确定并分析了1990年至2019年中国5-94岁男性和女性MDD的发病率趋势。包括年龄,时期和出生队列。
■分析揭示了与年龄有关的影响,表明青少年和老年人MDD风险增加。具体来说,在65~69岁时进入老年的个体,MDD的风险显著增加64.9%.90-94岁人群的MDD风险增加了105.4%。这个年龄段的女性和男性分别增长了75.1%和103.4%,分别。就时期效应而言,MDD的风险从1990年到1994年呈现下降趋势,随后在2008年出现反弹.队列效应表现出不同的世代模式,第一代和第三代表现出相反的“年龄水平”趋势。第二代和第四代表现出“累积劣势”和“累积优势”模式,分别。年龄效应表明女性MDD发病率总体较高,而队列效应显示女性MDD发病率差异较大。
■这项研究强调了年龄的重大影响,中国不同性别MDD的时期和队列研究。针对弱势群体的优先干预措施,包括孩子,青少年,老年人,女性和千年后出生队列,对于减轻MDD的影响至关重要。
UNASSIGNED: Major depressive disorders (MDDs) impose substantial burdens on individuals and society; however, further detailed analysis is still needed for its long-term trends.
UNASSIGNED: This study aimed to analyse the gender-specific temporal trends and cohort variations of MDD incidence among Chinese residents over the past three decades.
UNASSIGNED: Employing the age-period-cohort-interaction model and leveraging data from the Global Burden of Disease Study 2019, this research identified and analysed incidence trends of MDD among Chinese males and females aged 5-94 years from 1990 to 2019 across three dimensions, encompassing age, period and birth cohort.
UNASSIGNED: The analysis reveals age-related effects, indicating heightened MDD risk among adolescents and older adults. Specifically, individuals entering the older adulthood at the age of 65-69 significantly increased the risk of MDD by 64.9%. People aged 90-94 years witnessed a 105.4% increase in MDD risk for the overall population, with females and males in this age group experiencing a 75.1% and 103.4% increase, respectively. In terms of period effects, the risk of MDD displayed a decline from 1990 to 1994, followed by a rebound in 2008. Cohort effects demonstrated diverse generational patterns, with generation I and generation III manifesting opposing \'age-as-level\' trends. Generation II and generation IV exhibited \'cumulative disadvantage\' and \'cumulative advantage\' patterns, respectively. Age effects indicated an overall higher risk of MDD incidence in females, while cohort effects showed greater variations of MDD incidence among females.
UNASSIGNED: The study underscores the substantial effects of age, period and cohort on MDD across genders in China. Priority interventions targeting vulnerable populations, including children, adolescents, older adults, females and the post-millennium birth cohort, are crucial to mitigate the impact of MDD.