Abstract：
Chytridiomycosis is a devastating disease and is a key cause of amphibian population declines around the world. Despite active research on this amphibian disease system for over 2 decades, we still do not have treatment methods that are safe and that can be broadly used across species. Here, we show evidence that voriconazole is a successful method of treatment for 1 species of amphibian in captivity and that this treatment could offer benefits over other treatment options like heat or itraconazole, which are not able to be used for all species and life stages. We conducted 2 treatments of chytridiomycosis using voriconazole. The treatment was effective and resulted in 100% pathogen clearance, and mortality ceased. Additionally, treating frogs with voriconazole requires less handling than treatment methods like itraconazole and requires no specialized equipment, like heat treatment. We highlight that clinical treatment trials should be conducted to identify an optimum dosage and treatment time and that trials should test whether this treatment is safe and effective for tadpoles and other species.
摘要：
衣原体病是一种破坏性疾病，是全球两栖动物种群减少的主要原因。尽管对这种两栖动物疾病系统进行了超过20年的积极研究，我们仍然没有安全的治疗方法，可以广泛用于跨物种。这里,我们显示的证据表明，伏立康唑是一种成功的方法治疗1种两栖动物在圈养和这种治疗可以提供的好处比其他治疗方案，如热或伊曲康唑，不能用于所有物种和生命阶段。我们使用伏立康唑进行了2种治疗乳糜菌病。治疗是有效的，并导致100％的病原体清除，死亡停止了。此外,用伏立康唑治疗青蛙比伊曲康唑等治疗方法需要更少的处理，并且不需要专门的设备，比如热处理。我们强调应进行临床治疗试验以确定最佳剂量和治疗时间，并且试验应测试这种治疗对t和其他物种是否安全有效。
