Abstract：
Subjective memory complaints (SMCs) are a memory disorder that often precedes mild cognitive impairment (MCI) or Alzheimer\'s disease (AD). Both individual alpha rhythms and cognitive reserve (CR) represent key features of SMCs and provide useful tools to characterize and predict the course of the disorder. We studied whether older people with SMCs may also present some abnormal resting state electroencephalogram (rsEEG) alpha rhythms, and whether alpha rhythms are associated with CR. To do this, eyes-closed rsEEG were recorded in 68 older people with and without SMCs. The individual alpha indexes alpha/theta transition frequency (TF) and individual alpha frequency peak (IAFp) were computed. TF and IAFp were also used to determine the alpha1, alpha2, and alpha3 power frequency. Results indicated no differences in TF or IAFp between older people with SMCs and controls. The SMCs group showed a reduction in alpha3 power in comparison with controls. Specifically, women with SMCs were characterized by a significant decrease in alpha3 power compared to control women. Furthermore, only in SMCs group, greater CR was associated with slow IAFp. In sum, these results suggest that TF and IAFp are two stable indexes that are not influenced by the presence of SMCs. However, the reduction in alpha3, as observed in women with SMCs, shows an abnormal posterior rsEEG at alpha power. Finally, the compensatory mechanisms of CR appear to interact with the neurophysiological mechanisms that underlie the regulation of alpha rhythms.
摘要：
主观记忆不适（SMC）是一种记忆障碍，通常先于轻度认知障碍（MCI）或阿尔茨海默病（AD）。个体α节律和认知储备（CR）都代表了SMC的关键特征，并提供了表征和预测疾病进程的有用工具。我们研究了患有SMC的老年人是否也可能出现一些异常的静息状态脑电图（rsEEG）α节律，以及阿尔法节律是否与CR相关。要做到这一点，在有和没有SMC的68名老年人中记录了闭眼rsEEG。计算了单个α指数α/θ跃迁频率（TF）和单个α频率峰（IAFp）。TF和IAFp也用于确定α1、α2和α3功率频率。结果表明，患有SMC的老年人与对照组之间的TF或IAFp没有差异。与对照组相比，SMC组显示α3功率降低。具体来说,与对照女性相比,SMC女性的特点是α3功率显著下降.此外，仅在SMC组中，较高的CR与较慢的IAFp相关。总之,这些结果表明，TF和IAFp是两个不受SMC影响的稳定指标。然而,在患有SMC的女性中观察到的α3的减少，在α功率下显示异常的后rsEEG。最后,CR的代偿机制似乎与作为α节律调节基础的神经生理机制相互作用。
