Abstract：
An essential requirement for biomedical devices is the capability of conformal adaptability on diverse irregular 3D (three-dimensional) nonflat surfaces in the human body that may be covered with liquids such as mucus or sweat. However, the development of reversible adhesive interface materials for biodevices that function on complex biological surfaces is challenging due to the wet, slippery, smooth, and curved surface properties. Herein, we present an ultra-adaptive bioadhesive for irregular 3D oral cavities covered with saliva by integrating a kirigami-metastructure and vertically self-aligning suction cups. The flared suction cup, inspired by octopus tentacles, allows adhesion to moist surfaces. Additionally, the kirigami-based auxetic metastructure with a negative Poisson\'s ratio relieves the stress caused by tensile strain, thereby mitigating the stress caused by curved surfaces and enabling conformal contact with the surface. As a result, the adhesive strength of the proposed auxetic adhesive is twice that of adhesives with a flat backbone on highly curved porcine palates. For potential application, the proposed auxetic adhesive is mounted on a denture and performs successfully in human subject feasibility evaluations. An integrated design of these two structures may provide functionality and potential for biomedical applications.
摘要：
生物医学装置的基本要求是在人体中可能被液体如粘液或汗液覆盖的各种不规则3D(三维)非平坦表面上的共形适应性的能力。然而,在复杂的生物表面上起作用的生物器件的可逆粘合界面材料的开发具有挑战性，滑,光滑,和曲面属性。在这里，我们通过整合kirigami-meta结构和垂直自对准吸盘，为唾液覆盖的不规则3D口腔提供了一种超适应性生物粘合剂。扩口吸盘，受章鱼触手的启发，允许粘附到潮湿的表面。此外,具有负泊松比的基于kirigami的拉胀元结构减轻了由拉伸应变引起的应力，从而减轻由弯曲表面引起的应力并且使得能够与表面共形接触。因此,所提出的拉胀粘合剂的粘合强度是在高度弯曲的猪腭上具有平坦骨架的粘合剂的两倍。对于潜在的应用，拟议的拉胀粘合剂安装在义齿上，并在人类受试者的可行性评估中成功执行。这两种结构的集成设计可以为生物医学应用提供功能和潜力。
