Abstract：
BACKGROUND: Fragrance substances are a frequent cause of contact allergy worldwide. Fragrance exposure varies by sex, age and possibly country, influenced by cosmetic availability, environmental conditions and cultural practices.
OBJECTIVE: To systematically review and gather prevalence of sensitization to fragrance mix I (FM I) and fragrance mix II (FM II) in consecutively patch tested European dermatitis patients.
METHODS: A total of 4134 publications on patch test results of European dermatitis patients, published from 1981 to 2022, were systematically reviewed according to a previously registered and published PROSPERO protocol.
RESULTS: Eighty-four eligible original articles were analysed. Overall prevalence of sensitization to fragrance mix I (FM I) was 6.81% (95% CI: 6.37-7.28), and FM II was 3.64% (95% CI: 3.3-4.01). Sensitization to FM I was most prevalent in Central and Eastern Europe and to FM II in Western Europe. No clear time trends were observed. Among paediatric dermatitis patients, sensitization prevalence for FM I and FM II was 4.09% (95% CI: 3.37-4.96) and 2.17% (95% CI: 1.53-3.07).
CONCLUSIONS: The frequency of positive patch test results for both FMI and FMII remains high. Sensitization is also prevalent among children. Enhanced regulation and labelling of cosmetic products play a vital role in averting exposure and sensitization to fragrance allergens.
OBJECTIVE: To systematically review and gather prevalence of sensitization to fragrance mix I (FM I) and fragrance mix II (FM II) in consecutively patch tested European dermatitis patients.
METHODS: A total of 4134 publications on patch test results of European dermatitis patients, published from 1981 to 2022, were systematically reviewed according to a previously registered and published PROSPERO protocol.
RESULTS: Eighty-four eligible original articles were analysed. Overall prevalence of sensitization to fragrance mix I (FM I) was 6.81% (95% CI: 6.37-7.28), and FM II was 3.64% (95% CI: 3.3-4.01). Sensitization to FM I was most prevalent in Central and Eastern Europe and to FM II in Western Europe. No clear time trends were observed. Among paediatric dermatitis patients, sensitization prevalence for FM I and FM II was 4.09% (95% CI: 3.37-4.96) and 2.17% (95% CI: 1.53-3.07).
CONCLUSIONS: The frequency of positive patch test results for both FMI and FMII remains high. Sensitization is also prevalent among children. Enhanced regulation and labelling of cosmetic products play a vital role in averting exposure and sensitization to fragrance allergens.
摘要：
背景：芳香物质是全球接触过敏的常见原因。香味暴露程度因性别而异，年龄和可能的国家，受化妆品可用性的影响，环境条件和文化习俗。
目的：系统地回顾和收集连续斑贴测试的欧洲皮炎患者对香料混合物I（FMI）和香料混合物II（FMII）的致敏率。
方法：共有4134篇关于欧洲皮炎患者斑贴试验结果的出版物，从1981年到2022年发布，根据以前注册和发布的PROSPERO协议进行了系统审查。
结果：分析了84篇合格的原始文章。香料混合物I（FMI）的致敏总体患病率为6.81％（95％CI：6.37-7.28），FMII为3.64%（95%CI：3.3-4.01）。对FMI的敏感性在中欧和东欧最为普遍，对FMII的敏感性在西欧最为普遍。没有观察到明显的时间趋势。在儿科皮炎患者中，FMI和FMII的致敏患病率分别为4.09%(95%CI:3.37-4.96)和2.17%(95%CI:1.53-3.07).
结论：FMI和FMII的斑贴试验结果阳性的频率仍然很高。致敏在儿童中也很普遍。增强化妆品的监管和标签在避免对香料过敏原的暴露和致敏中起着至关重要的作用。
目的：系统地回顾和收集连续斑贴测试的欧洲皮炎患者对香料混合物I（FMI）和香料混合物II（FMII）的致敏率。
方法：共有4134篇关于欧洲皮炎患者斑贴试验结果的出版物，从1981年到2022年发布，根据以前注册和发布的PROSPERO协议进行了系统审查。
结果：分析了84篇合格的原始文章。香料混合物I（FMI）的致敏总体患病率为6.81％（95％CI：6.37-7.28），FMII为3.64%（95%CI：3.3-4.01）。对FMI的敏感性在中欧和东欧最为普遍，对FMII的敏感性在西欧最为普遍。没有观察到明显的时间趋势。在儿科皮炎患者中，FMI和FMII的致敏患病率分别为4.09%(95%CI:3.37-4.96)和2.17%(95%CI:1.53-3.07).
结论：FMI和FMII的斑贴试验结果阳性的频率仍然很高。致敏在儿童中也很普遍。增强化妆品的监管和标签在避免对香料过敏原的暴露和致敏中起着至关重要的作用。
