背景:手部湿疹(HE)是一种常见的皮肤病,在职业性和非职业性环境中对患者的生活质量有负面影响。最新的,缺乏接受斑贴试验的意大利患者的HE数据.
目的:从人口统计学的角度来描述概况,病因学和斑贴试验结果的意大利患者受他提到的斑贴试验。
方法:对2016年至2023年在8家皮肤科诊所接受斑贴检测的连续HE患者进行了回顾性描述性研究。HE患者根据手受累情况分为两组(仅HE组)和非特异性(HE+组),并与位于手部以外的身体部位的湿疹患者进行比较(NHE组)。
结果:一千五百九十七个患者受到HE的影响(男性占35.3%,平均年龄42.7岁),60.2%属于仅HE组,39.8%属于HE+组。在仅HE的患者中,有33.2%诊断为职业性皮炎,25.0%的HE+患者和5.2%的NHE患者(p<0.001)。仅出现HE的患者:过敏性接触性皮炎(ACD),刺激性接触性皮炎(ICD),特应性HE占48.1%,47.5%和7.1%,分别;手掌角化过度,急性复发性水泡型和血球型临床亚型占52.2%,43.9%和11.9%,分别为48.1%(硫酸镍18.9%,甲基氯异噻唑啉酮/甲基异噻唑啉酮10.6%,甲基异噻唑啉酮8.6%,对苯二胺6.0%和重铬酸钾4.7%)。
结论:HE患者,尤其是那些独家参与的人,在人口统计学和临床特征方面显示特定的特征,病因和相关阳性斑贴试验反应。
BACKGROUND: Hand eczema (HE) is a common skin disease with a negative impact on patients\' quality of life in occupational and non-occupational settings. Up-to-date, data on HE in Italian patients referred for patch testing are lacking.
OBJECTIVE: To characterise the profile in terms of demographics, aetiology and patch test results of Italian patients affected by HE referred for patch testing.
METHODS: A retrospective descriptive study on consecutive patients affected by HE who underwent patch testing from 2016 to 2023 in eight dermatology clinics was performed. HE patients were divided into two groups according to the exclusive (HE-only group) and not-exclusive (HE+ group) hand involvement, and compared to patients with eczema localised in body areas other than hands (NHE group).
RESULTS: One thousand five hundred and ninety-seven patients were affected by HE (35.3% males; mean age 42.7 years), 60.2% belonging to the HE-only group and 39.8% to the HE+ group. Occupational dermatitis was diagnosed in 33.2% of HE-only patients, 25.0% of HE+ patients and 5.2% of NHE patients (p < 0.001). HE-only patients presented: Allergic Contact Dermatitis (ACD), Irritant Contact Dermatitis (ICD), atopic HE in 48.1%, 47.5% and 7.1%, respectively; hyperkeratotic palmar, acute recurrent vesicular and nummular clinical subtypes in 52.2%, 43.9% and 11.9%, respectively; relevant positive patch test reactions in 48.1% (nickel sulphate 18.9%, methylchloroisothiazolinone/methylisothiazolinone 10.6%, methylisothiazolinone 8.6%, p-phenylenediamine 6.0% and potassium dichromate 4.7%).
CONCLUSIONS: HE patients, and particularly those with exclusive hand involvement, show a particular profile in terms of demographic and clinical characteristics, etiologies and relevant positive patch test reactions.