{Reference Type}: Journal Article
{Title}: Contact sensitization to fragrance mix I and fragrance mix II among European dermatitis patients: A systematic review.
{Author}: Botvid S;Bennike NH;Simonsen AB;Johansen JD;Uter W;
{Journal}: Contact Dermatitis
{Volume}: 91
{Issue}: 3
{Year}: 2024 Sep 30
{Factor}: 6.419
{DOI}: 10.1111/cod.14618
{Abstract}: <B>BACKGROUND: </B>Fragrance substances are a frequent cause of contact allergy worldwide. Fragrance exposure varies by sex, age and possibly country, influenced by cosmetic availability, environmental conditions and cultural practices.<BR><B>OBJECTIVE: </B>To systematically review and gather prevalence of sensitization to fragrance mix I (FM I) and fragrance mix II (FM II) in consecutively patch tested European dermatitis patients.<BR><B>METHODS: </B>A total of 4134 publications on patch test results of European dermatitis patients, published from 1981 to 2022, were systematically reviewed according to a previously registered and published PROSPERO protocol.<BR><B>RESULTS: </B>Eighty-four eligible original articles were analysed. Overall prevalence of sensitization to fragrance mix I (FM I) was 6.81% (95% CI: 6.37-7.28), and FM II was 3.64% (95% CI: 3.3-4.01). Sensitization to FM I was most prevalent in Central and Eastern Europe and to FM II in Western Europe. No clear time trends were observed. Among paediatric dermatitis patients, sensitization prevalence for FM I and FM II was 4.09% (95% CI: 3.37-4.96) and 2.17% (95% CI: 1.53-3.07).<BR><B>CONCLUSIONS: </B>The frequency of positive patch test results for both FMI and FMII remains high. Sensitization is also prevalent among children. Enhanced regulation and labelling of cosmetic products play a vital role in averting exposure and sensitization to fragrance allergens.