PDF(Pubmed)
Abstract：
UNASSIGNED: The incidence of perioperative neurocognitive disorders (PND) is high, especially after cardiac surgeries, and the underlying mechanisms remain elusive. Here, we conducted a prospective observational study to observe serum proteomics differences in PND patients after cardiac valve replacement surgery.
UNASSIGNED: Two hundred and twenty-six patients who underwent cardiac valve surgery were included. They were categorized based on scoring into non-PND group (group non-P) and PND group (group P\'). The risk factors associated with PND were analyzed. These patients were further divided into group C and group P by propensity score matching (PSM) to investigate the serum proteome related to the PND by serum proteomics.
UNASSIGNED: The postoperative 6-week incidence of PND was 16.8%. Risk factors for PND include age, chronic illness, sufentanil dosage, and time of cardiopulmonary bypass (CPB). Proteomics identified 31 down-regulated proteins and six up-regulated proteins. Finally, GSTO1, IDH1, CAT, and PFN1 were found to be associated with PND.
UNASSIGNED: The occurrence of PND can impact some oxidative stress proteins. This study provided data for future studies about PND to general anaesthesia and surgeries.
UNASSIGNED: Two hundred and twenty-six patients who underwent cardiac valve surgery were included. They were categorized based on scoring into non-PND group (group non-P) and PND group (group P\'). The risk factors associated with PND were analyzed. These patients were further divided into group C and group P by propensity score matching (PSM) to investigate the serum proteome related to the PND by serum proteomics.
UNASSIGNED: The postoperative 6-week incidence of PND was 16.8%. Risk factors for PND include age, chronic illness, sufentanil dosage, and time of cardiopulmonary bypass (CPB). Proteomics identified 31 down-regulated proteins and six up-regulated proteins. Finally, GSTO1, IDH1, CAT, and PFN1 were found to be associated with PND.
UNASSIGNED: The occurrence of PND can impact some oxidative stress proteins. This study provided data for future studies about PND to general anaesthesia and surgeries.
摘要：
■围手术期神经认知障碍（PND）的发生率很高，尤其是在心脏手术后,潜在的机制仍然难以捉摸。这里,我们进行了一项前瞻性观察性研究,以观察心脏瓣膜置换术后PND患者的血清蛋白质组学差异.
■纳入了接受心脏瓣膜手术的二百二十六例患者。根据评分分为非PND组（非P组）和PND组（P组）。分析与PND相关的危险因素。根据倾向评分匹配(PSM)将这些患者进一步分为C组和P组,通过血清蛋白质组学研究与PND相关的血清蛋白质组。
■术后6周PND发生率为16.8%。PND的危险因素包括年龄，慢性病,舒芬太尼用量,和体外循环（CPB）的时间。蛋白质组学鉴定出31种下调蛋白和6种上调蛋白。最后,GSTO1,IDH1,CAT,PFN1与PND有关。
■PND的发生可以影响一些氧化应激蛋白。这项研究为未来有关PND的全身麻醉和手术研究提供了数据。
■纳入了接受心脏瓣膜手术的二百二十六例患者。根据评分分为非PND组（非P组）和PND组（P组）。分析与PND相关的危险因素。根据倾向评分匹配(PSM)将这些患者进一步分为C组和P组,通过血清蛋白质组学研究与PND相关的血清蛋白质组。
■术后6周PND发生率为16.8%。PND的危险因素包括年龄，慢性病,舒芬太尼用量,和体外循环（CPB）的时间。蛋白质组学鉴定出31种下调蛋白和6种上调蛋白。最后,GSTO1,IDH1,CAT,PFN1与PND有关。
■PND的发生可以影响一些氧化应激蛋白。这项研究为未来有关PND的全身麻醉和手术研究提供了数据。
