%0 Journal Article
%T Serum proteomics study on cognitive impairment after cardiac valve replacement surgery: a prospective observational study.
%A Ma H
%A Wei Y
%A Chen W
%A Chen S
%A Wang Y
%A Cao S
%A Wang H
%J PeerJ
%V 12
%N 0
%D 2024
%M 38912047
%F 3.061
%R 10.7717/peerj.17536
%X <B>UNASSIGNED: </B>The incidence of perioperative neurocognitive disorders (PND) is high, especially after cardiac surgeries, and the underlying mechanisms remain elusive. Here, we conducted a prospective observational study to observe serum proteomics differences in PND patients after cardiac valve replacement surgery.<BR><B>UNASSIGNED: </B>Two hundred and twenty-six patients who underwent cardiac valve surgery were included. They were categorized based on scoring into non-PND group (group non-P) and PND group (group P'). The risk factors associated with PND were analyzed. These patients were further divided into group C and group P by propensity score matching (PSM) to investigate the serum proteome related to the PND by serum proteomics.<BR><B>UNASSIGNED: </B>The postoperative 6-week incidence of PND was 16.8%. Risk factors for PND include age, chronic illness, sufentanil dosage, and time of cardiopulmonary bypass (CPB). Proteomics identified 31 down-regulated proteins and six up-regulated proteins. Finally, GSTO1, IDH1, CAT, and PFN1 were found to be associated with PND.<BR><B>UNASSIGNED: </B>The occurrence of PND can impact some oxidative stress proteins. This study provided data for future studies about PND to general anaesthesia and surgeries.