结核病(TB)是一种传染病,仍然是全球主要的公共卫生问题之一。因此,早期发现活动性肺结核对于控制致死率和疾病传播至关重要。目前可用的结核病诊断可以大致分为显微镜,以文化为基础,和分子方法,所有这些都伴随着敏感性受损,功效有限,和高费用。因此,快速,敏感,和负担得起的结核病诊断方法是目前疾病管理的先决条件。这篇综述总结了来自血清的宿主特异性生物标志物的蛋白质组学研究。痰,唾液,结核病患者的尿液样本,以及患有合并症的患者。从现有文献中进行彻底的数据挖掘使我们得出结论,参与免疫和防御的宿主特异性蛋白质,代谢调节,细胞粘附,和运动性,炎症反应,和组织重塑在结核分枝杆菌(Mtb)感染后显示出明显的失调。值得注意的是,与非结核病人相比,活动性结核病中的免疫调节蛋白类(ORM)上调,正如在来自不同样本类型的多项研究中观察到的那样。甘露糖受体C2型(MRC2)被鉴定为上调,两个独立的血清蛋白质组学研究中的治疗反应生物标志物。对这些候选蛋白质进行彻底的机械研究将是吸引人的,以挖掘潜在的药物靶标和针对结核病患者的定制疗法。以及他们的诊断潜力。
Tuberculosis (TB) is an infectious disease that remains one of the major global public health concerns. Early detection of Active Pulmonary TB is therefore of utmost importance for controlling lethality and disease spreading. Currently available TB diagnostics can be broadly categorized into microscopy, culture-based, and molecular approaches, all of which come with compromised sensitivity, limited efficacy, and high expenses. Hence, rapid, sensitive, and affordable diagnostic methods for TB is the current prerequisite for disease management. This review summarizes the
proteomics investigations for host-specific biomarkers from serum, sputum, saliva, and urine samples of TB patients, along with patients having comorbidity. Thorough data mining from available literature led us to conclude that the host-specific proteins involved in immunity and defense, metabolic regulation, cellular adhesion, and motility, inflammatory responses, and tissue remodelling have shown significant deregulation upon Mycobacterium tuberculosis (Mtb) infection. Notably, the immunoregulatory protein orosomucoid (ORM) was up-regulated in active TB compared to non-TB individuals, as observed in multiple studies from diverse sample types. Mannose receptor C type 2 (MRC2) was identified as an upregulated, treatment response biomarker in two independent serum
proteomics investigations. Thorough mechanistic investigation on these candidate proteins would be fascinating to dig into potential drug targets and customized therapeutics for TB patients, along with their diagnostic potentials.