PDF(Pubmed)
Abstract：
Disruptions in appetite-regulating hormones may contribute to the development and/or maintenance of avoidant/restrictive food intake disorder (ARFID). No study has previously assessed fasting levels of orexigenic ghrelin or anorexigenic peptide YY (PYY), nor their trajectory in response to food intake among youth with ARFID across the weight spectrum. We measured fasting and postprandial (30, 60, 120 minutes post-meal) levels of ghrelin and PYY among 127 males and females with full and subthreshold ARFID (n = 95) and healthy controls (HC; n = 32). We used latent growth curve analyses to examine differences in the trajectories of ghrelin and PYY between ARFID and HC. Fasting levels of ghrelin did not differ in ARFID compared to HC. Among ARFID, ghrelin levels declined more gradually than among HC in the first hour post meal (p =.005), but continued to decline between 60 and 120 minutes post meal, whereas HC plateaued (p =.005). Fasting and PYY trajectory did not differ by group. Findings did not change after adjusting for BMI percentile (M(SD)ARFID = 37(35); M(SD)HC = 53(26); p =.006) or calories consumed during the test meal (M(SD)ARFID = 294(118); M(SD)HC = 384 (48); p <.001). These data highlight a distinct trajectory of ghrelin following a test meal in youth with ARFID. Future research should examine ghrelin dysfunction as an etiological or maintenance factor of ARFID.
摘要：
食欲调节激素的破坏可能有助于避免性/限制性食物摄入障碍（ARFID）的发展和/或维持。以前没有研究评估过食欲释放肽或食欲减退肽YY（PYY）的空腹水平，在不同体重范围内，他们对ARFID青少年食物摄入量的反应轨迹也没有。我们在127名男性和女性中测量了空腹和餐后（餐后30、60、120分钟）的ghrelin和PYY水平。我们使用潜在生长曲线分析来检查ARFID和HC之间ghrelin和PYY轨迹的差异。与HC相比，ARFID中ghrelin的空腹水平没有差异。在ARFID中，在餐后的第一个小时，ghrelin水平比HC下降得更缓慢(p=0.005)，但在用餐后60到120分钟之间继续下降，而HC趋于稳定（p=0.005）。禁食和PYY轨迹在各组之间没有差异。调整BMI百分位数（M（SD）ARFID=37（35）；M（SD）HC=53（26）；p=.006）或测试进餐期间消耗的卡路里（M（SD）ARFID=294（118）；M（SD）HC=384（48）；p<.001）后，结果没有变化。这些数据突出了在使用ARFID的年轻人中进行测试餐后ghrelin的独特轨迹。未来的研究应该检查生长素释放肽功能障碍作为ARFID的病因或维持因素。
