Meals

膳食
  • 文章类型: Journal Article
    随着现代生活的快节奏,人们吃饭的时间更少,但是很少有研究研究过快速饮食习惯与代谢性疾病之间的关联。
    结合当前研究和先前研究的结果,我们旨在探讨快速饮食与代谢功能障碍相关脂肪变性肝病(MASLD)风险之间的可能关系.
    这是对1965名参与者的多中心横断面研究的子分析,调查了中国人快速饮食与MASLD之间的关联。快速进食被定义为用餐时间少于五分钟,参与者根据他们自我报告的快速进食频率分为三类:≤1次/月,≤1次/周且≥2次/周。我们进一步对11月之前发表的可用研究进行了文献检索,2023年以及一项荟萃分析,以调查快速饮食与MASLD之间的关系。
    MASLD的比例为59.3%,50.5%,46.2%的参与者快速进食≥2次/周,≤1次/周,≤1次/月,分别(趋势P<0.001)。在多次调整性别后,快速进食的频率与MASLD的风险独立相关,年龄,人口统计,吸烟和饮酒状况,BMI和临床代谢参数(OR,1.29;95CI,1.09-1.53)。频繁进食(≥2次/周)的参与者发生MASLD的风险高81%(P=0.011)。对五项符合条件的研究进行的荟萃分析证实,频繁的快速进食与MASLD的风险增加有关(汇总OR,1.22;95CI,1.07-1.39)。
    频繁的快速进食与MASLD的风险增加有关。
    With the fast pace of modern life, people have less time for meals, but few studies have examined the association between the habit of fast eating and metabolic diseases.
    Combining the results of the current study and the prior ones, we aimed to investigate the possible relationship between fast eating and the risk of metabolic dysfunction-associated steatotic liver disease (MASLD).
    This is a sub-analysis of a multicenter cross-sectional study of 1965 participants investigated the association between fast eating and MASLD in Chinese. Fast eating was defined as meal time less than five minutes and participants were divided into three categories based on their self-reported frequency of fast eating: ≤1 time/month, ≤1 time/week and ≥2 times/week. We further conducted a literature search for available studies published before November, 2023 as well as a meta-analysis to investigate the association between fast eating and MASLD.
    The proportion of MASLD was 59.3%, 50.5%, and 46.2% in participants with fast eating ≥2 times/week, ≤1 time/week and ≤1 time/month, respectively (P for trend <0.001). The frequency of fast eating was independently associated with risk of MASLD after multiple adjustment for sex, age, demographics, smoking and drinking status, BMI and clinical metabolic parameters (OR, 1.29; 95%CI, 1.09-1.53). Participants who ate fast frequently (≥2 times/week) had 81% higher risk of MASLD (P = 0.011). A meta-analysis of five eligible studies confirmed that frequent fast eating was associated with increased risk of MASLD (pooled OR, 1.22; 95%CI, 1.07-1.39).
    Frequent fast eating was associated with an increased risk of MASLD.
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  • 文章类型: Journal Article
    背景:2型糖尿病(T2D)管理的基石是改变生活方式,包括健康饮食,通常是碳水化合物提供总能量摄入的45%-60%(E%)。然而,对T2D低碳水化合物饮食(蛋白质和/或脂肪增加)试验的系统评价和荟萃分析发现,与碳水化合物含量较高的对照饮食相比,前几个月的血糖控制有所改善.持续≥1年的研究尚无定论,这可能是由于长期饮食依从性下降。我们假设糖代谢益处可以在限制碳水化合物节食12个月后实现。通过提供餐包来最大化饮食依从性,含有新鲜的,早餐的优质食材,晚餐和小吃,结合营养教育和咨询。
    方法:本方案描述了一项为期12个月的研究者启动的随机对照研究,开放标签,在两个平行组进行的优势试验中,将在100名T2D和体重指数(BMI)>25kg/m2的个体中,研究与常规糖尿病(CD)饮食相比,减少碳水化合物高蛋白(CRHP)饮食对糖代谢控制(主要结局为糖化血红蛋白的变化)的影响.参与者将被随机分为1:1,以接受CRHP或CD饮食(包含30/50E%的碳水化合物,30/17E%来自蛋白质,40/33E%来自脂肪,分别)作为餐包交付12个月,含有超过三分之二的参与者的食物,估计每天维持体重所需的能量。通过注册临床营养师每月的营养教育和咨询会议,将加强对分配饮食的遵守。
    背景:该试验已获得丹麦首都地区国家卫生研究伦理委员会的批准。审判将根据赫尔辛基宣言进行。结果将提交国际同行评审的科学期刊上发表。
    背景:NCT05330247。
    方法:试验方案于2022年3月9日获得批准(研究编号:H-21057605)。协议的最新版本,在这份手稿中描述,2023年6月23日批准。
    BACKGROUND: The cornerstone in the management of type 2 diabetes (T2D) is lifestyle modification including a healthy diet, typically one in which carbohydrate provides 45%-60% of total energy intake (E%). Nevertheless, systematic reviews and meta-analyses of trials with low carbohydrate diets (which are increased in protein and/or fat) for T2D have found improved glycaemic control in the first months relative to comparator diets with higher carbohydrate content. Studies lasting ≥1 year are inconclusive, which could be due to decreased long-term dietary adherence. We hypothesise that glucometabolic benefits can be achieved following 12 months of carbohydrate-restricted dieting, by maximising dietary adherence through delivery of meal kits, containing fresh, high-quality ingredients for breakfast, dinner and snacks, combined with nutrition education and counselling.
    METHODS: This protocol describes a 12-month investigator-initiated randomised controlled, open-label, superiority trial with two parallel groups that will examine the effect of a carbohydrate-reduced high-protein (CRHP) diet compared with a conventional diabetes (CD) diet on glucometabolic control (change in glycated haemoglobin being the primary outcome) in 100 individuals with T2D and body mass index (BMI) >25 kg/m2. Participants will be randomised 1:1 to receive either the CRHP or the CD diet (comprised 30/50 E% from carbohydrate, 30/17 E% from protein and 40/33 E% from fat, respectively) for 12 months delivered as meal kits, containing foods covering more than two-thirds of the participants\' estimated daily energy requirements for weight maintenance. Adherence to the allocated diets will be reinforced by monthly sessions of nutrition education and counselling from registered clinical dietitians.
    BACKGROUND: The trial has been approved by the National Committee on Health Research Ethics of the Capital Region of Denmark. The trial will be conducted in accordance with the Declaration of Helsinki. Results will be submitted for publication in international peer-reviewed scientific journals.
    BACKGROUND: NCT05330247.
    METHODS: The trial protocol was approved on 9 March 2022 (study number: H-21057605). The latest version of the protocol, described in this manuscript, was approved on 23 June 2023.
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  • 文章类型: Journal Article
    Chronotype是一个既定的概念,旨在捕获现实生活条件下的内部时钟相位。它在日常生活的许多方面都至关重要,并且会严重干扰给定人群中的许多因素。在研究时间型和健康状况之间的联系时,识别不可改变和可改变的因素对于识别感兴趣的协变量至关重要。迄今为止,时间型及其相关因素尚未得到广泛研究。本研究旨在探讨时序型与进餐频率的关系,身体活动,和沙特人口中的人口因素。这份基于网络的横断面问卷涉及沙特阿拉伯公众的1369名成年人(18岁及以上),于2019年3月至5月进行。使用原始Horne和Ostberg早晚性问卷(MEQ)的简化版本评估时序型。用餐频率和人口统计数据(年龄,性别,婚姻状况,居住地,教育水平,就业状况,收入)获得。还使用国际身体活动问卷获得了身体活动水平。MEQ评分将个人分为三类:早晨型,两种类型,晚上型。两种类型的个体占41.6%(95%置信区间[CI],37.5%-45.6%)的研究人群,其次是早晨型(34.1%;95%[CI],29.8%-38.4%),然后是晚上型(24.3%,95%[CI],19.6%-28.9%)。时序型与年龄显著相关,婚姻状况,就业状况和月收入(均p<0.05)。时间型与进餐频率之间存在显著关联(每天进餐次数,早餐频率,午餐频率,和晚餐频率)和身体活动也观察到(所有p<0.05)。这项研究强调,进餐频率和身体活动水平与时间型分布有关。此外,人口统计,包括年龄,婚姻状况,就业状况,和收入,与时间型分布有关。
    Chronotype is an established concept designed to capture the internal clock\'s phase in real-life conditions. It is vital in many aspects of daily life and can interfere considerably with numerous factors in a given population. Recognizing nonmodifiable and modifiable factors is crucial for identifying covariates of interest when studying the link between chronotype and health status. To date, chronotype and its related factors have not been extensively investigated. The present study aimed to explore the association of chronotypes with meal frequency, physical activity, and demographic factors among the Saudi population. This cross-sectional web-based questionnaire involved 1369 adults (aged 18 years and above) from the general public in Saudi Arabia and was conducted between March and May 2019. Chronotype was assessed using the reduced version of the original Horne and Ostberg morningness-eveningness questionnaire (MEQ). Meal frequencies and demographics data (age, gender, marital status, place of residence, educational level, employment status, income) were obtained. Physical activity level was also obtained using the international physical activity questionnaire. The MEQ scores group individuals into three categories: morning-type, neither-type, and evening-type. The neither-type individuals represented 41.6% (95% confidence interval [CI], 37.5% - 45.6%) of the study population, followed by the morning-type (34.1%; 95% [CI], 29.8% - 38.4%), then the evening-type (24.3%, 95% [CI], 19.6% - 28.9%). Chronotype was significantly associated with age, marital status, employment status and monthly income (All p < 0.05). Significant associations between chronotype with meal frequencies (number of meals per day, breakfast frequency, lunch frequency, and dinner frequency) and physical activity were also observed (All p < 0.05). This study highlights that meal frequencies and physical activity levels are associated with chronotype distribution. Furthermore, demographics, including age, marital status, employment status, and income, were associated with chronotype distribution.
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    文章类型: Journal Article
    目的:分析幼儿园前计划中提供的膳食的致癌性及其对社会经济弱势儿童的早期龋齿(ECC)风险的潜在影响。方法:这项研究在联合国儿童发展中心检查了超过43天的123份学校提供的膳食,奥克兰统一学区幼儿园计划的一部分。使用Evans等人开发的致龋指数。,对所供应的所有项目进行了食品和饮料的致龋潜力评估.结果:食品的平均每日致龋评分为6.57±1.3(标准偏差),饮料的平均每日致龋评分为2.89±0.78。早餐食品的致龋作用明显高于午餐或晚餐(P<0.05)。平均每日卡路里摄入量为1,459±336,与晚餐相比,午餐的卡路里含量具有统计学意义(P<0.05)。虽然液体可能不会显著增加龋齿风险,早餐食品成为一个潜在的问题。结论:这项研究的结果表明,学校膳食中提供的食物,特别是早餐,可能会影响社会经济弱势儿童的早期龋齿风险。鉴于ECC的流行及其社会负担,将食品和饮料致龋性评估纳入学校膳食计划可能有助于降低ECC发生率。美国农业部和学区在考虑食物的致龋潜力方面的合作可能有助于改善儿童早期的口腔健康结果。
    Purpose: To analyze the cariogenicity of meals served in a pre-kindergarten program and its potential influence on early childhood caries (ECC) risk in socioeconomically disadvantaged children. Methods: This study examined 123 school-provided meals over 43 days at the United Nation Childhood Development Center, part of the Oakland Unified School District pre-kindergarten program. Using cariogenicity indices developed by Evans et al., all items served were assessed for the cariogenic potential of both food and beverages. Results: The mean daily cariogenicity scores were 6.57±1.3 (standard deviation) for food and 2.89±0.78 for beverages. Breakfast foods were significantly more cariogenic than those served for lunch or supper (P<0.05). The mean daily calorie intake was 1,459±336, with lunch containing statistically higher calorie items compared to supper (P<0.05). While liquids may not significantly contribute to caries risk, breakfast foods emerged as a potential concern. Conclusions: This study\'s findings suggest that the food provided in school meals, particularly breakfast items, may impact early childhood caries risk among socioeconomically disadvantaged children. Given the prevalence of ECC and its societal burden, integrating assessments of food and beverage cariogenicity into school meal planning could be instrumental in mitigating ECC incidence. Collaboration between the United States Department of Agriculture and school districts in considering the cariogenic potential of foods may contribute to improved oral health outcomes in early childhood.
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  • 文章类型: Journal Article
    白宫关于饥饿的国家战略,营养,健康包括向所有学生提供免费的校餐,无论收入如何,这在美国引发了争论。
    评估美国普遍免费学校餐(UFSM)与学校和学生成绩之间的关联。
    制定了专家小组知情方案,以评估比较UFSM计划的干预或队列研究,例如社区资格规定(CEP),2012年8月(不包括由于COVID-19大流行而导致的2020-2021年)在美国学校开展非UFSM课程。结果包括膳食参与率,出席,饮食摄入量和质量,食物浪费,经济影响,粮食不安全,人体测量学,纪律处分,污名,和羞辱。搜索Medline,Econlit,最终的业务来源,ERIC,Agricola,CabAbstracts,和CINAHL于2024年4月进行。两名研究人员筛选了纳入的文章,提取的数据,并评估了偏见的风险,在非随机干预研究工具中使用偏倚风险,对于每个纳入的研究。建议的分级,评估,发展,评估用于评估每个结果的证据的确定性。
    搜索确定了2784条记录,包括6项研究,代表超过11000个小学,中间,和高中。非随机干预研究进行差异或比率分析以调查CEP参与率,出席,人体测量学,和/或悬架。CEP与增加午餐(3项研究;中等确定性)和早餐(1项研究;非常低的确定性)相关。与没有UFSM的学校相比,有CEP的学校的入学率没有变化或有所改善(2项研究;确定性低)。CEP与较低的肥胖患病率(1项研究;非常低的确定性)和较少的悬浮(1项研究;非常低的确定性)相关。降低确定性评级的原因包括间接性(数据不能完全代表美国)和不一致性(少量研究限制了评估一致性的能力)。尽管有局限性,证据反映了设计良好的纵向干预研究,适合于决策.
    在这篇系统综述中,UFSM与增加的膳食参与有关,出勤率没有或略有改善,肥胖患病率和中止率降低;午餐参与的证据确定性适中,其他结局的证据确定性较低或非常低.研究没有报告几个重要的结果,如饮食质量和粮食安全,这表明需要更多高质量的研究,包括与政策相关的指标。
    UNASSIGNED: The White House National Strategy on Hunger, Nutrition, and Health included expanding free school meals to all students, regardless of income, which has sparked debate in the United States.
    UNASSIGNED: To assess the association between universal free school meals (UFSMs) and school and student outcomes in the United States.
    UNASSIGNED: An expert panel-informed protocol was developed to evaluate intervention or cohort studies comparing UFSM programs, such as the Community Eligibility Provision (CEP), with non-UFSM programs in US schools from August 2012 (excluding 2020-2021 due to the COVID-19 pandemic) in peer-reviewed publications or government reports. Outcomes included meal participation rates, attendance, dietary intake and quality, food waste, economic impact, food insecurity, anthropometrics, disciplinary actions, stigma, and shaming. A search of Medline, Econlit, Business Source Ultimate, ERIC, Agricola, Cab Abstracts, and CINAHL was performed in April 2024. Two researchers screened articles for inclusion, extracted data, and assessed risk of bias, using the Risk of Bias in Nonrandomized Studies of Interventions tool, for each included study. Grading of Recommendations, Assessment, Development, and Evaluations was used to assess the certainty of evidence for each outcome.
    UNASSIGNED: The search identified 2784 records, with 6 studies included, representing more than 11 000 elementary, middle, and high schools. Nonrandomized intervention studies performed difference-in-difference or rate ratio analysis to investigate CEP participation rates, attendance, anthropometrics, and/or suspensions. CEP was associated with increased lunch (3 studies; moderate certainty) and breakfast (1 study; very low certainty) participation. School attendance was unchanged or improved in schools with CEP compared with schools without UFSM (2 studies; low certainty). CEP was associated with lower obesity prevalence (1 study; very low certainty) and fewer suspensions (1 study; very low certainty). Reasons for downgrading the certainty ratings included indirectness (data not fully representative of the United States) and inconsistency (small number of studies limiting ability to assess consistency). Despite the limitations, the evidence reflected well-designed longitudinal intervention studies appropriate for decision-making.
    UNASSIGNED: In this systematic review, UFSMs were associated with increased meal participation, no or slight improvements in attendance, and decreased obesity prevalence and suspension rates; certainty of evidence was moderate for lunch participation and low or very low for other outcomes. Studies did not report several important outcomes, such as diet quality and food security, suggesting the need for more high-quality research encompassing policy-relevant indicators.
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  • 文章类型: Journal Article
    目标:比较在社区咖啡厅(咖啡厅)用餐的饮食质量,一家可以付费的餐馆,食物不安全的客人在前一天(比较餐)在同等饮食场合食用的一餐。
    方法:从有食物不安全的咖啡馆客人那里收集饮食召回,以确定健康饮食指数-2020(HEI-2020)总分和成分得分。使用配对样本t检验和Wilcoxon符号秩检验比较了膳食之间的健康饮食指数-2020得分。
    结果:大多数参与者(n=40;80%男性;42.5%黑人)的食品安全性非常低(70.0%)。咖啡餐具有较高的HEI-2020总分(46.7±10.5vs34.4±11.6;P<0.001)和总蔬菜(2.6±2.0vs1.2±1.7;P=0.004),总果实(2.1±2.2vs0.6±1.5;P<0.001),全果(1.6±2.0vs0.3±0.9;P<0.001),和精制谷物(7.8±3.5vs3.9±3.9;P<0.001)得分高于对照膳食。
    结论:咖啡馆餐的饮食质量优于比较餐,这表明它有可能改善食物不安全的客人的饮食质量。
    OBJECTIVE: Compare the diet quality of a meal consumed at a community café (café meals), a pay-what-you-can restaurant, to a meal consumed for an equivalent eating occasion on the day before (comparison meal) by guests with food insecurity.
    METHODS: Dietary recalls were collected from café guests with food insecurity to determine the Healthy Eating Index-2020 (HEI-2020) total and component scores. Healthy Eating Index-2020 scores were compared between meals using paired-sample t tests and Wilcoxon signed-rank tests.
    RESULTS: Most participants (n = 40; 80% male; 42.5% Black) had very low food security (70.0%). Café meal had a higher HEI-2020 total score (46.7 ± 10.5 vs 34.4 ± 11.6; P < 0.001) and total vegetables (2.6 ± 2.0 vs 1.2 ± 1.7; P = 0.004), total fruits (2.1 ± 2.2 vs 0.6 ± 1.5; P < 0.001), whole fruits (1.6 ± 2.0 vs 0.3 ± 0.9; P < 0.001), and refined grains (7.8 ± 3.5 vs 3.9 ± 3.9; P < 0.001) scores than comparison meals.
    CONCLUSIONS: The café meal had better diet quality than the comparison meal, suggesting its potential for improving diet quality among guests with food insecurity.
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  • 文章类型: Journal Article
    目的:本研究旨在探索便利店作为健康食品消费平台的潜力,包括低钠选项,以应对便利店用餐行为日益增长的趋势和对健康饮食日益增长的需求。
    方法:在研究中,627名10至39岁的韩国参与者参与其中。使用了自我报告的问卷调查,并提出了有关购买模式的问题,消费行为,便利店食品的感知和选择属性,和消费者对低钠选择的感知因素。数据分析采用SPSS26.0(SPSS,Windows版本26.0,SPSSInc.,芝加哥,IL,美国)。
    结果:该研究发现了便利店食品的消费行为和感知方面的显着差异,以及便利店食品属性的重要性和满意度的变化,包括消费者对低钠选择的感知因素,基于性别和年龄。此外,研究发现,对低钠选项需求的认识显著影响了购买意愿.
    结论:本研究分析了消费者对低钠便利店食品的态度,以评估在便利店促进健康饮食的潜力。这些发现表明,便利店可以作为健康食品销售平台发挥重要作用。
    OBJECTIVE: This study aims to explore the potential of convenience stores as platforms for healthy food consumption, including low-sodium options, in response to the increasing trend of meal behaviors at convenience stores and the growing demand for healthy eating.
    METHODS: In the study, 627 Korean participants aged 10 to 39 were involved. A self-reported questionnaire survey was used and questions were regarding purchase patterns, consumption behaviors, perceptions and selection attributes of convenience store foods, and consumer perception factors for low-sodium options. Data analysis was conducted using SPSS 26.0 (SPSS, Version 26.0 for Windows, SPSS Inc., Chicago, IL, USA).
    RESULTS: The study uncovered significant disparities in the consumption behavior and perception of convenience store foods, as well as variations in the importance and satisfaction levels with convenience store food attributes, including consumer perception factors for low-sodium options, based on sex and age. Furthermore, it was observed that awareness of the need for low-sodium options significantly influenced purchase intentions.
    CONCLUSIONS: This study analyzed consumer attitude toward low-sodium convenience store foods to assess the potentiality for promoting healthy eating in convenience stores. These findings indicate the important role that convenience stores can play as platforms for healthy food sales.
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  • 文章类型: Journal Article
    基于大型语言模型的人工智能聊天机器人最近已经成为传统在线搜索的替代品,并且也正在进入营养领域。在这项研究中,我们想调查人工智能聊天机器人ChatGPT和Bard(现在的双子座)是否可以创建满足不同饮食模式的饮食参考摄入量(DRI)的膳食计划。我们进一步假设可以通过修改使用的提示来改善营养充足性。膳食计划由3个不同膳食模式的账户生成(杂食性,素食主义者,和素食主义者)使用2个不同的提示,总共产生108个膳食计划。随后分析计划的营养素含量并与DRI进行比较。平均而言,膳食计划包含更少的能量和碳水化合物,但大部分超过蛋白质的DRI。维生素D和氟化物低于所有计划的DRI,而只有素食计划含有不足的维生素B12。ChatGPT建议在18例中的5例中使用维生素B12补充剂,而Bard从不推荐补充剂。提示或工具之间没有显着差异。尽管ChatGPT和Bard生成的膳食计划符合大多数DRI,有一些例外,特别是素食。这些工具可能对寻找一般饮食灵感的人有用,但是不应该依靠它们来制定营养充足的膳食计划,特别是对于有限制性饮食需求的人。
    Artificial intelligence chatbots based on large language models have recently emerged as an alternative to traditional online searches and are also entering the nutrition space. In this study, we wanted to investigate whether the artificial intelligence chatbots ChatGPT and Bard (now Gemini) can create meal plans that meet the dietary reference intake (DRI) for different dietary patterns. We further hypothesized that nutritional adequacy could be improved by modifying the prompts used. Meal plans were generated by 3 accounts for different dietary patterns (omnivorous, vegetarian, and vegan) using 2 distinct prompts resulting in 108 meal plans total. The nutrient content of the plans was subsequently analyzed and compared to the DRIs. On average, the meal plans contained less energy and carbohydrates but mostly exceeded the DRI for protein. Vitamin D and fluoride fell below the DRI for all plans, whereas only the vegan plans contained insufficient vitamin B12. ChatGPT suggested using vitamin B12 supplements in 5 of 18 instances, whereas Bard never recommended supplements. There were no significant differences between the prompts or the tools. Although the meal plans generated by ChatGPT and Bard met most DRIs, there were some exceptions, particularly for vegan diets. These tools maybe useful for individuals looking for general dietary inspiration, but they should not be relied on to create nutritionally adequate meal plans, especially for individuals with restrictive dietary needs.
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  • 文章类型: Journal Article
    目的:本研究旨在探讨车轮上餐(MoWs)服务用户(SU)的感知,以及将它们推荐给MoWs的人(“推荐人”),随着在英国访问和开始这项服务,可能阻碍服务吸收的障碍,以及在考虑访问该服务时将重视哪些信息。
    方法:2022年5月至7月进行了半结构化访谈,对7名SU和21名推荐人进行了访谈,从英格兰的四个MoW供应商招募。采用归纳专题分析法对数据进行分析。
    结果:参与者指出了进入服务的各种途径,但是推荐人(家庭成员)更有可能是询问的人,并开始,SUs的MoW。一旦对MoW进行了询问,该服务被认为是简单的设置。然而,现有的成见和刻板印象被认为是进入MoW的障碍。参与者在决定是否访问与膳食相关的MoW时认为重要的信息,提供的具体服务,交付的可靠性和灵活性以及服务成本。
    结论:这些发现可以为MoW服务提供商提供有关MoW的公众意识策略,为有护理和支持需求的成年人提供服务。
    拥有MoWs(服务的用户及其家庭推荐人)生活经验的咨询小组广泛讨论了研究结果,并就其含义和未来的传播步骤提供了建议。
    OBJECTIVE: This study aimed to explore the perceptions of Meals on Wheels (MoWs) service users (SUs), and people who refer them to MoWs (\'referrers\'), with accessing and commencing the service in England, the barriers that might hinder service uptake, and what information would be valued when considering accessing the service.
    METHODS: Semistructured interviews were conducted in May-July 2022 with seven SUs and 21 referrers, recruited from four MoWs providers across England. Data were analysed using inductive thematic analysis.
    RESULTS: Participants indicated various pathways into the service, but referrers (family members) were more likely to be the ones enquiring about, and commencing, MoWs for SUs. Once an enquiry about MoWs had been made, the service was perceived as straightforward to set up. However, existing preconceptions and stereotypes were perceived to act as barriers to accessing MoWs. Information that participants deemed important to have available when deciding on whether to access MoWs related to the meals, the specific services provided, the reliability and flexibility of delivery and the cost of services.
    CONCLUSIONS: These findings could inform MoWs service providers\' public awareness strategies about MoWs, to facilitate referrals to the service for adults with care and support needs.
    UNASSIGNED: An advisory group of people with lived experience of MoWs (users of the service and their family referrers) extensively discussed the findings of the research and advised on the implications and future dissemination steps.
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  • 文章类型: Journal Article
    在1型糖尿病中,高脂肪膳食需要更多的胰岛素来预防高血糖,而有氧运动需要更少的胰岛素来预防低血糖,但是需要的调整因人而异。我们提出了一个具有强化学习功能的决策支持系统,以个性化高脂饮食和餐后有氧运动的胰岛素剂量。我们在一项为期16周的单臂研究中对15名成年人进行了多次每日注射治疗(NCT05041621)。本研究的主要目的是评估新型学习算法的可行性。这项研究着眼于血糖结果和患者报告的结果。从基线到高脂肪膳食的评估期,餐后葡萄糖曲线下的增量面积得到改善(378±222vs38±223mmol/L/min,p=0.03)和运动后进餐(-395±192vs132±181mmol/L/min,p=0.007)。高脂饮食后,餐后低于3.9mmol/L的时间减少(5.3±1.6vs1.8±1.5%,p=0.003)和进餐后进行锻炼(5.3±1.2vs1.4±1.1%,p=0.003)。我们的研究表明,自动个性化胰岛素剂量用于高脂肪膳食和餐后锻炼的可行性。随机对照试验是必要的。
    In type 1 diabetes, high-fat meals require more insulin to prevent hyperglycemia while meals followed by aerobic exercises require less insulin to prevent hypoglycemia, but the adjustments needed vary between individuals. We propose a decision support system with reinforcement learning to personalize insulin doses for high-fat meals and postprandial aerobic exercises. We test this system in a single-arm 16-week study in 15 adults on multiple daily injections therapy (NCT05041621). The primary objective of this study is to assess the feasibility of the novel learning algorithm. This study looks at glucose outcomes and patient reported outcomes. The postprandial incremental area under the glucose curve is improved from the baseline to the evaluation period for high-fat meals (378 ± 222 vs 38 ± 223 mmol/L/min, p = 0.03) and meals followed by exercises (-395 ± 192 vs 132 ± 181 mmol/L/min, p = 0.007). The postprandial time spent below 3.9 mmol/L is reduced after high-fat meals (5.3 ± 1.6 vs 1.8 ± 1.5%, p = 0.003) and meals followed by exercises (5.3 ± 1.2 vs 1.4 ± 1.1%, p = 0.003). Our study shows the feasibility of automatically personalizing insulin doses for high-fat meals and postprandial exercises. Randomized controlled trials are warranted.
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