目的:进食障碍(ED)通常在青春期出现。在那些关键的发育时期,父母的联系对孩子的心理健康有持久的影响。父母关系是否是发展或维持特定ED的风险因素仍然存在不确定性,更确切地说,一般精神病理学和相关的潜在脑功能。
方法:41名年轻成年健康对照个体(HC,26.6±3.5年)和46例ED(25例神经性厌食症,AN,22.8±6.4年,21患有神经性贪食症,BN,23.5±4.2年)完成了父母粘合工具(PBI),对焦虑的评估,抑郁症,和ED行为,并在脑成像过程中接受了调理范例。
结果:在两组中,感知的父母照顾和过度保护与状态和特质焦虑以及人际关系疏远相关,仅在HC中,身体不满和追求瘦身的动力。患有ED的个人报告自我感知的父母照料较低,但与HC组相比,过度保护更高。伏核(NAc)反应与两组的结合措施有关,正确的NAc反应介导了母亲护理与HC特质焦虑之间的关系。
结论:感知父母结合与一般精神病理学有关,包括HC和ED组的焦虑和人际关系困难。较低的父母护理和较高的过度保护可能会使健康个体容易出现身体形状或体重问题;然而,other,也许生物学因素可以决定一个人是否会发展为ED。感知到的父母关系之间的联系,NAc效价处理和焦虑暗示多巴胺能回路,应进一步研究。
方法:III级:病例对照分析研究。
OBJECTIVE: Eating disorders (EDs) typically emerge during adolescence. Parental bonding has a lasting impact on a child\'s mental health during those developmentally critical years. There remains uncertainty over whether parental bonding is a risk factor for developing or maintaining specifically EDs or, rather, general psychopathology and the associated underlying brain function.
METHODS: Forty-one young adult healthy control individuals (HC, 26.6 ± 3.5 years) and 46 individuals with EDs (25 with anorexia nervosa, AN, 22.8 ± 6.4 years, and 21 with bulimia nervosa, BN, 23.5 ± 4.2 years) completed the parental bonding instrument (PBI), assessments for anxiety, depression, and ED behaviors, and underwent a conditioning paradigm during brain imaging.
RESULTS: In both groups, perceived parental care and overprotection were correlated with state and trait anxiety and interpersonal alienation, and in HC only, with body dissatisfaction and drive for thinness. Individuals with an ED reported lower self-perceived parental care, but higher overprotection compared to the HC group. Nucleus accumbens (NAc) response was related to bonding measures in both groups and right NAc response mediated the relationship between maternal care and trait anxiety in HC.
CONCLUSIONS: Perceived parental bonding is associated with general psychopathology, including elevated anxiety and interpersonal difficulties across HC and ED groups. Lower perceived parental care and higher overprotection could predispose healthy individuals to develop problems with body shape or weight; however, other, maybe biological factors may determine whether a person will develop an ED. The link between perceived parental bonding, NAc valence processing and anxiety implicates dopaminergic circuits that should be studied further.
METHODS: Level III: Case-control analytic study.