PDF(Pubmed)
Abstract：
Theory predicts that compensatory genetic changes reduce negative indirect effects of selected variants during adaptive evolution, but evidence is scarce. Here, we test this in a wild population of Hawaiian crickets using temporal genomics and a high-quality chromosome-level cricket genome. In this population, a mutation, flatwing, silences males and rapidly spread due to an acoustically-orienting parasitoid. Our sampling spanned a social transition during which flatwing fixed and the population went silent. We find long-range linkage disequilibrium around the putative flatwing locus was maintained over time, and hitchhiking genes had functions related to negative flatwing-associated effects. We develop a combinatorial enrichment approach using transcriptome data to test for compensatory, intragenomic coevolution. Temporal changes in genomic selection were distributed genome-wide and functionally associated with the population\'s transition to silence, particularly behavioural responses to silent environments. Our results demonstrate how \'adaptation begets adaptation\'; changes to the sociogenetic environment accompanying rapid trait evolution can generate selection provoking further, compensatory adaptation.
摘要：
理论预测，补偿性遗传变化会减少适应性进化过程中选定变异的间接负面影响，但证据很少.这里,我们使用时间基因组学和高质量染色体水平的板球基因组在夏威夷的野生种群中进行了测试。在这个人群中,一个突变,平翼,由于声学定向的寄生虫，使雄性沉默并迅速传播。我们的抽样跨越了社会转型，在此期间，平稳过渡，人口保持沉默。我们发现，随着时间的推移，假定的平翼轨迹周围的长期连锁不平衡得以维持，搭便车基因具有与平翼相关的负效应相关的功能。我们开发了一种组合富集方法，使用转录组数据来测试补偿性，基因组内协同进化。基因组选择的时间变化分布在全基因组范围内，并且在功能上与种群向沉默的过渡相关。特别是对沉默环境的行为反应。我们的结果证明了“适应产生适应”；伴随快速性状进化的社会遗传环境的变化可以进一步激发选择，补偿性适应。
