PDF(Pubmed)
Abstract：
Noroviruses are the second leading cause of death in children under the age of 5 years old. They are responsible for 200 million cases of diarrhoea and 50,000 deaths in children through the word, mainly in low-income countries. The objective of this review was to assess how the prevalence and genetic diversity of noroviruses have been affected by the introduction of rotavirus vaccines in Africa. PubMed, Web of Science and Science Direct databases were searched for articles. All included studies were conducted in Africa in children aged 0 to 5 years old with gastroenteritis. STATA version 16.0 software was used to perform the meta-analysis. The method of Dersimonian and Laird, based on the random effects model, was used for the statistical analyses in order to estimate the pooled prevalence\'s at a 95% confidence interval (CI). Heterogeneity was assessed by Cochran\'s Q test using the I2 index. The funnel plot was used to assess study publication bias. A total of 521 studies were retrieved from the databases, and 19 were included in the meta-analysis. The pooled norovirus prevalence\'s for pre- and post-vaccination rotavirus studies were 15% (95 CI, 15-18) and 13% (95 CI, 09-17) respectively. GII was the predominant genogroup, with prevalence of 87.64% and 91.20% respectively for the pre- and post-vaccination studies. GII.4 was the most frequently detected genotype, with rates of 66.84% and 51.24% respectively for the pre- and post-vaccination studies. This meta-analysis indicates that rotavirus vaccination has not resulted in a decrease in norovirus infections in Africa.
摘要：
诺罗病毒是5岁以下儿童死亡的第二大原因。他们负责2亿腹泻病例和5万儿童死亡，主要是低收入国家。本综述的目的是评估非洲轮状病毒疫苗的引入如何影响诺如病毒的流行和遗传多样性。PubMed,搜索了WebofScience和ScienceDirect数据库中的文章。所有纳入的研究都是在非洲0至5岁患有肠胃炎的儿童中进行的。使用STATA16.0版软件进行荟萃分析。Dersimonian和Laird的方法，基于随机效应模型，用于统计分析，以95%置信区间(CI)估计合并患病率。使用I2指数通过Cochran'sQ检验评估异质性。漏斗图用于评估研究发表偏倚。总共从数据库中检索到521项研究，19例纳入荟萃分析.疫苗接种前和接种后轮状病毒研究的混合诺如病毒感染率分别为15%(95CI,15-18)和13%(95CI,09-17)。GII是主要的基因组，疫苗接种前和接种后研究的患病率分别为87.64%和91.20%。GII.4是最常见的基因型，接种前和接种后研究的发病率分别为66.84%和51.24%。这项荟萃分析表明，轮状病毒疫苗接种并未导致非洲诺如病毒感染的减少。
