RESULTS: QDTP-Zn demonstrated alleviation of UC symptoms in mice, as evidenced by a decrease in disease activity index scores. QDTP-Zn also regulated colon tissue injury by upregulating ZO-1 and occludin protein expression, at the same time as downregulating tumor necrosis factor-α and interleukin-6β levels. Furthermore, QDTP-Zn induced significant alterations in the abundance of bacteroidetes and firmicutes and notably increased levels of short-chain fatty acids (SCFAs), particularly acetic acid, propionic acid, and butyric acid.
CONCLUSIONS: In summary, QDTP-Zn exhibits therapeutic potential in alleviating enteritis by fortifying the colonic mucosal barrier, mitigating inflammation and modulating intestinal microbiota and SCFAs levels. Thus, QDTP-Zn holds promise as a functional food for both the prevention and treatment of UC. © 2024 Society of Chemical Industry.
结果:QDTP-Zn证明了小鼠UC症状的缓解,疾病活动指数得分下降证明了这一点。QDTP-Zn还通过上调ZO-1和occludin蛋白表达来调节结肠组织损伤,同时下调肿瘤坏死因子-α和白细胞介素-6β水平。此外,QDTP-Zn诱导了大量的抑菌作用和固定蛋白的显着变化,并显着增加了短链脂肪酸(SCFA)的水平,特别是乙酸,丙酸,还有丁酸.
结论:总之,QDTP-Zn在强化结肠粘膜屏障缓解肠炎方面表现出治疗潜力,减轻炎症和调节肠道微生物群和SCFA水平。因此,QDTP-Zn有望作为预防和治疗UC的功能性食品。©2024化学工业学会。