Abstract：
BACKGROUND: Qingzhuan dark tea polysaccharides (QDTP) have been complexed with Zinc (Zn) to form the Qingzhuan dark tea polysaccharides-Zinc (QDTP-Zn) complex. The present study investigated the protective effects of QDTP-Zn on ulcerative colitis (UC) in mice. The UC mouse model was induced using dextran sodium sulfate (DSS), followed by oral administration of QDTP-Zn (0.2 and 0.4 g kg-1 day-1).
RESULTS: QDTP-Zn demonstrated alleviation of UC symptoms in mice, as evidenced by a decrease in disease activity index scores. QDTP-Zn also regulated colon tissue injury by upregulating ZO-1 and occludin protein expression, at the same time as downregulating tumor necrosis factor-α and interleukin-6β levels. Furthermore, QDTP-Zn induced significant alterations in the abundance of bacteroidetes and firmicutes and notably increased levels of short-chain fatty acids (SCFAs), particularly acetic acid, propionic acid, and butyric acid.
CONCLUSIONS: In summary, QDTP-Zn exhibits therapeutic potential in alleviating enteritis by fortifying the colonic mucosal barrier, mitigating inflammation and modulating intestinal microbiota and SCFAs levels. Thus, QDTP-Zn holds promise as a functional food for both the prevention and treatment of UC. © 2024 Society of Chemical Industry.
RESULTS: QDTP-Zn demonstrated alleviation of UC symptoms in mice, as evidenced by a decrease in disease activity index scores. QDTP-Zn also regulated colon tissue injury by upregulating ZO-1 and occludin protein expression, at the same time as downregulating tumor necrosis factor-α and interleukin-6β levels. Furthermore, QDTP-Zn induced significant alterations in the abundance of bacteroidetes and firmicutes and notably increased levels of short-chain fatty acids (SCFAs), particularly acetic acid, propionic acid, and butyric acid.
CONCLUSIONS: In summary, QDTP-Zn exhibits therapeutic potential in alleviating enteritis by fortifying the colonic mucosal barrier, mitigating inflammation and modulating intestinal microbiota and SCFAs levels. Thus, QDTP-Zn holds promise as a functional food for both the prevention and treatment of UC. © 2024 Society of Chemical Industry.
摘要：
背景：青竹黑茶多糖（QDTP）已与锌（Zn）络合形成青竹黑茶多糖-锌（QDTP-Zn）络合物。本研究探讨了QDTP-Zn对小鼠溃疡性结肠炎（UC）的保护作用。使用葡聚糖硫酸钠（DSS）诱导UC小鼠模型，然后口服QDTP-Zn（0.2和0.4gkg-1day-1）。
结果：QDTP-Zn证明了小鼠UC症状的缓解，疾病活动指数得分下降证明了这一点。QDTP-Zn还通过上调ZO-1和occludin蛋白表达来调节结肠组织损伤，同时下调肿瘤坏死因子-α和白细胞介素-6β水平。此外，QDTP-Zn诱导了大量的抑菌作用和固定蛋白的显着变化，并显着增加了短链脂肪酸（SCFA）的水平，特别是乙酸，丙酸,还有丁酸.
结论：总之，QDTP-Zn在强化结肠粘膜屏障缓解肠炎方面表现出治疗潜力，减轻炎症和调节肠道微生物群和SCFA水平。因此，QDTP-Zn有望作为预防和治疗UC的功能性食品。©2024化学工业学会。
结果：QDTP-Zn证明了小鼠UC症状的缓解，疾病活动指数得分下降证明了这一点。QDTP-Zn还通过上调ZO-1和occludin蛋白表达来调节结肠组织损伤，同时下调肿瘤坏死因子-α和白细胞介素-6β水平。此外，QDTP-Zn诱导了大量的抑菌作用和固定蛋白的显着变化，并显着增加了短链脂肪酸（SCFA）的水平，特别是乙酸，丙酸,还有丁酸.
结论：总之，QDTP-Zn在强化结肠粘膜屏障缓解肠炎方面表现出治疗潜力，减轻炎症和调节肠道微生物群和SCFA水平。因此，QDTP-Zn有望作为预防和治疗UC的功能性食品。©2024化学工业学会。
