%0 Journal Article
%T Qingzhuan dark tea polysaccharides-zinc alleviates dextran sodium sulfate-induced ulcerative colitis.
%A Zheng M
%A Xie C
%A Ye D
%A Chen Y
%A Wang Z
%A Wang L
%A Xiong F
%A Zhang S
%A He Q
%A Wu H
%A Wu Z
%A Zhou H
%A Li L
%A Xing J
%A Miao X
%J J Sci Food Agric
%V 104
%N 12
%D 2024 Sep 24
%M 38785267
%F 4.125
%R 10.1002/jsfa.13597
%X <B>BACKGROUND: </B>Qingzhuan dark tea polysaccharides (QDTP) have been complexed with Zinc (Zn) to form the Qingzhuan dark tea polysaccharides-Zinc (QDTP-Zn) complex. The present study investigated the protective effects of QDTP-Zn on ulcerative colitis (UC) in mice. The UC mouse model was induced using dextran sodium sulfate (DSS), followed by oral administration of QDTP-Zn (0.2 and 0.4 g kg-1 day-1).<BR><B>RESULTS: </B>QDTP-Zn demonstrated alleviation of UC symptoms in mice, as evidenced by a decrease in disease activity index scores. QDTP-Zn also regulated colon tissue injury by upregulating ZO-1 and occludin protein expression, at the same time as downregulating tumor necrosis factor-α and interleukin-6β levels. Furthermore, QDTP-Zn induced significant alterations in the abundance of bacteroidetes and firmicutes and notably increased levels of short-chain fatty acids (SCFAs), particularly acetic acid, propionic acid, and butyric acid.<BR><B>CONCLUSIONS: </B>In summary, QDTP-Zn exhibits therapeutic potential in alleviating enteritis by fortifying the colonic mucosal barrier, mitigating inflammation and modulating intestinal microbiota and SCFAs levels. Thus, QDTP-Zn holds promise as a functional food for both the prevention and treatment of UC. © 2024 Society of Chemical Industry.