{Reference Type}: Journal Article
{Title}: Qingzhuan dark tea polysaccharides-zinc alleviates dextran sodium sulfate-induced ulcerative colitis.
{Author}: Zheng M;Xie C;Ye D;Chen Y;Wang Z;Wang L;Xiong F;Zhang S;He Q;Wu H;Wu Z;Zhou H;Li L;Xing J;Miao X;
{Journal}: J Sci Food Agric
{Volume}: 104
{Issue}: 12
{Year}: 2024 Sep 24
{Factor}: 4.125
{DOI}: 10.1002/jsfa.13597
{Abstract}: <B>BACKGROUND: </B>Qingzhuan dark tea polysaccharides (QDTP) have been complexed with Zinc (Zn) to form the Qingzhuan dark tea polysaccharides-Zinc (QDTP-Zn) complex. The present study investigated the protective effects of QDTP-Zn on ulcerative colitis (UC) in mice. The UC mouse model was induced using dextran sodium sulfate (DSS), followed by oral administration of QDTP-Zn (0.2 and 0.4 g kg-1 day-1).<BR><B>RESULTS: </B>QDTP-Zn demonstrated alleviation of UC symptoms in mice, as evidenced by a decrease in disease activity index scores. QDTP-Zn also regulated colon tissue injury by upregulating ZO-1 and occludin protein expression, at the same time as downregulating tumor necrosis factor-α and interleukin-6β levels. Furthermore, QDTP-Zn induced significant alterations in the abundance of bacteroidetes and firmicutes and notably increased levels of short-chain fatty acids (SCFAs), particularly acetic acid, propionic acid, and butyric acid.<BR><B>CONCLUSIONS: </B>In summary, QDTP-Zn exhibits therapeutic potential in alleviating enteritis by fortifying the colonic mucosal barrier, mitigating inflammation and modulating intestinal microbiota and SCFAs levels. Thus, QDTP-Zn holds promise as a functional food for both the prevention and treatment of UC. © 2024 Society of Chemical Industry.