■血清微量元素和氧化应激因子与糖尿病微血管并发症有关。这项研究是为了调查微量元素之间的复杂关系,氧化应激因素,以及老年人糖尿病微血管并发症的严重程度。
■本研究包括有或没有2型糖尿病的患者,和血糖,血脂,微量元素(铁,镁,锌),氧化应激因素(丙二醛(MDA),一氧化氮(NO),超氧化物歧化酶(SOD),和总抗氧化能力(T-AOC)进行评估。还估计了老年糖尿病患者糖尿病微血管并发症严重程度的危险因素。
■空腹血糖(FBG)差异有统计学意义,甘油三酯(TG),低密度脂蛋白(LDL),糖化血红蛋白(HbAlc),MDA,NO,SOD,T-AOC,镁,两组间锌含量差异有统计学意义(P<0.05)。铁(rZn=0.147,rSOD=0.180,rT-AOC=0.193,P<0.05)与锌呈正相关,SOD和T-AOC。铁与MDA呈负相关(rMDA=-0.146,P<0.05)。镁与SOD呈正相关(r镁=0.147,P<0.05)。锌(rSOD=0.616,rT-AOC=0.575,P<0.01)与SOD、T-AOC呈正相关。锌(rMDA=-0.636,rNO=-0.616,P<0.01)与MDA呈正相关,与NO呈负相关。病程(18.653,[5.726;60.764],P<0.01),FBG(1.265,[1.059;1.511],P<0.05),HbAlc(1.545,[1.431;1.680],P<0.01),MDA(2.989,[1.900;4.702],P<0.01)是糖尿病微血管并发症严重程度的危险因素。锌(0.680,[0.503;0.919],P<0.05)和SOD(0.820,[0.698;0.964],P<0.05)是糖尿病微血管并发症严重程度的保护因素。
■血清微量元素与2型糖尿病老年人的氧化应激水平有关。老年糖尿病患者的微量元素更稳定,氧化应激越低,糖尿病微血管并发症越少。
UNASSIGNED: Serum trace elements and oxidative stress factors are related to diabetic microvascular complications. The study was to investigate the complex relationship between trace elements, oxidative stress factors, and the severity of microvascular complications of diabetes in older adults.
UNASSIGNED: The present study included patients with or without type 2 diabetes, and blood glucose, blood lipids, trace elements (iron, magnesium,
zinc), oxidative stress factors (malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), and total antioxidant capacity (T-AOC)) were evaluated. Risk factors for the severity of diabetic microvascular complications in older adults with diabetes were also estimated.
UNASSIGNED: There were statistically significant differences in fasting blood glucose (FBG), triglycerides (TG), low density lipoprotein (LDL), glycated hemoglobin (HbAlc), MDA, NO, SOD, T-AOC, magnesium, and
zinc between the two groups (P<0.05). Iron (rZinc = 0.147, rSOD = 0.180, rT-AOC = 0.193, P < 0.05) was positively correlated with
zinc, SOD and T-AOC. Iron was negatively correlated with MDA (rMDA = -0.146, P < 0.05). Magnesium was positively correlated with SOD (rMagnesium = 0.147, P < 0.05).
Zinc (rSOD = 0.616, rT-AOC = 0.575, P < 0.01) was positively correlated with SOD and T-AOC.
Zinc (rMDA =-0.636, rNO=-0.616, P<0.01) was positively correlated with MDA and negatively correlated with NO. The course of disease (18.653, [5.726; 60.764], P <0.01), FBG (1.265, [1.059; 1.511], P <0.05), HbAlc (1.545, [1.431; 1.680], P <0.01), MDA (2.989, [1.900; 4.702], P <0.01) were risk factor for the severity of diabetic microvascular complications. Zinc (0.680, [0.503; 0.919], P < 0.05) and SOD (0.820, [0.698; 0.964], P < 0.05) were protective factors for the severity of diabetic microvascular complications.
UNASSIGNED: Serum trace elements are related to oxidative stress levels in older adults with type 2 diabetes. The more stable trace element in older adults with diabetes, the lower the oxidative stress and the fewer microvascular complications of diabetes.