PDF(Pubmed)
Abstract：
UNASSIGNED: Duchenne muscular dystrophy (DMD) is a devastating X-linked muscle disease. Clinical evaluation of DMD uses patient-intensive motor function tests, and the recent development of wearable devices allows the collection of a variety of biometric information, including physical activity.
UNASSIGNED: In this study, we examined differences in physical activity and heart rate variability (HRV) between patients with DMD and healthy subjects using a wearable device, and investigated any association between these parameters and motor function in patients with DMD.
UNASSIGNED: Participants were 7 patients with DMD and 8 healthy males, whose physical activity and HRV were provided by a wearable device. These data were used to investigate the relationship between both physical activity and HRV parameters and timed motor functional tests [Time to stand from supine, 10-meter walking time (10MWT), North Star Ambulatory Assessment (NSAA), and 6-minute walking test (6MWT)] in patients with DMD.
UNASSIGNED: Results of 24-hours physical activity, fat burning, total number of steps and active distance, average step rate, average exercise intensity during walking, exercise, degree of forward lean during walking, maximum heart rate, normalized low frequency power (LF norm), and maximum exercise intensity in patients with DMD were lower than those in control subjects. Physical activity and HRV parameters did not correlate with the time to stand from supine. The 10MWT positively correlated with average heart rate, while NSAA negatively correlated with average heart rate, total frequency power (TF), and very low frequency power (VLF) during arousal. The 6MWT negatively correlated with ratio LF/high frequency power (HF).
UNASSIGNED: Physical activity and HRV indices that differ from those of normal children and that correlate with motor function assessment may serve as digital biomarkers.
UNASSIGNED: In this study, we examined differences in physical activity and heart rate variability (HRV) between patients with DMD and healthy subjects using a wearable device, and investigated any association between these parameters and motor function in patients with DMD.
UNASSIGNED: Participants were 7 patients with DMD and 8 healthy males, whose physical activity and HRV were provided by a wearable device. These data were used to investigate the relationship between both physical activity and HRV parameters and timed motor functional tests [Time to stand from supine, 10-meter walking time (10MWT), North Star Ambulatory Assessment (NSAA), and 6-minute walking test (6MWT)] in patients with DMD.
UNASSIGNED: Results of 24-hours physical activity, fat burning, total number of steps and active distance, average step rate, average exercise intensity during walking, exercise, degree of forward lean during walking, maximum heart rate, normalized low frequency power (LF norm), and maximum exercise intensity in patients with DMD were lower than those in control subjects. Physical activity and HRV parameters did not correlate with the time to stand from supine. The 10MWT positively correlated with average heart rate, while NSAA negatively correlated with average heart rate, total frequency power (TF), and very low frequency power (VLF) during arousal. The 6MWT negatively correlated with ratio LF/high frequency power (HF).
UNASSIGNED: Physical activity and HRV indices that differ from those of normal children and that correlate with motor function assessment may serve as digital biomarkers.
摘要：
■杜氏肌营养不良症（DMD）是一种破坏性的X连锁肌肉疾病。DMD的临床评估使用患者密集的运动功能测试，以及可穿戴设备的最新发展允许收集各种生物特征信息，包括体力活动。
■在这项研究中，我们使用可穿戴设备检查了DMD患者和健康受试者之间的身体活动和心率变异性（HRV）的差异，并调查了DMD患者这些参数与运动功能之间的任何关联。
■参与者是7名DMD患者和8名健康男性，其身体活动和HRV由可穿戴设备提供。这些数据用于研究身体活动和HRV参数与定时运动功能测试之间的关系[仰卧站立时间，10米步行时间（10MWT），北极星门诊评估（NSAA）和DMD患者的6分钟步行测试（6MWT）]。
■24小时体力活动的结果，脂肪燃烧,总步数和活动距离，平均步进率，步行期间的平均运动强度，锻炼,行走过程中向前倾斜的程度，最大心率,归一化低频功率(LF范数)，DMD患者的最大运动强度低于对照组。身体活动和HRV参数与仰卧站立的时间无关。10MWT与平均心率呈正相关,而NSAA与平均心率呈负相关,总频率功率(TF)，和唤醒期间的极低频功率(VLF)。6MWT与比率LF/高频功率（HF）呈负相关。
■与正常儿童不同且与运动功能评估相关的身体活动和HRV指数可以作为数字生物标志物。
■在这项研究中，我们使用可穿戴设备检查了DMD患者和健康受试者之间的身体活动和心率变异性（HRV）的差异，并调查了DMD患者这些参数与运动功能之间的任何关联。
■参与者是7名DMD患者和8名健康男性，其身体活动和HRV由可穿戴设备提供。这些数据用于研究身体活动和HRV参数与定时运动功能测试之间的关系[仰卧站立时间，10米步行时间（10MWT），北极星门诊评估（NSAA）和DMD患者的6分钟步行测试（6MWT）]。
■24小时体力活动的结果，脂肪燃烧,总步数和活动距离，平均步进率，步行期间的平均运动强度，锻炼,行走过程中向前倾斜的程度，最大心率,归一化低频功率(LF范数)，DMD患者的最大运动强度低于对照组。身体活动和HRV参数与仰卧站立的时间无关。10MWT与平均心率呈正相关,而NSAA与平均心率呈负相关,总频率功率(TF)，和唤醒期间的极低频功率(VLF)。6MWT与比率LF/高频功率（HF）呈负相关。
■与正常儿童不同且与运动功能评估相关的身体活动和HRV指数可以作为数字生物标志物。
