Abstract：
OBJECTIVE: The objective of this study was to evaluate and compare Optical Coherence Tomography Angiography (OCTA) parameters in patients with moderate myopia and healthy individuals retrospectively.
METHODS: A total of 80 male individuals aged 18-20 years were included in the study with 40 moderate myopic and 40 healthy persons. All participants underwent detailed ocular examination including refraction, intraocular pressure (IOP), visual acuity, biomicroscopy, OCTA measurement and optic biometry measurement. Retinal, retinal nerve fiber layer and choroidal layer thicknesses were evaluated in µm with the help of the software available in the OCTA device.
RESULTS: The mean axial length (24.32 ± 0.53 mm) was statistically significantly higher in the moderate myopic group (24.32 mm) compared to the healthy group (23.33 ± 0.61 mm) (p < 0.001). Spherical equivalent (SE) was found as -3.79 ± 0.91 D in the moderate myopic group and -0.22 ± 0.32 D in the healthy group (p < 0.05). The mean superficial foveal mean density (FovSupMVD) and the mean deep foveal mean density (FovDepMVD) were statistically significantly lower in the moderate myopic group than in the healthy group (both, p < 0.001). The mean retinal temporal thickness (RTt) was statistically significantly lower in the moderate myopic group (p = 0.017). There was a mild negative correlation between axial length and FovSupMVD, FovDepMVD in myopes. In axial length ROC analysis, the cutoff value for moderate myopes was found to be 24.15 mm. Mean superficial foveal mean density (FovSupMVD) and mean deep foveal mean density (FovDepMVD), mean retinal temporal thickness (RTt) were significantly lower in the group above 24.15 mm axial length compared to the group below 24.15 mm axial length (all three, p < 0.001). Foveal avascular zone was significantly higher in the group above 24.15 mm axial length (p = 0.016) CONCLUSION: The results of our study indicate that the mean axial length and spherical equivalent were significantly higher, while retinal temporal thickness, the mean superficial foveal mean density and the mean deep foveal mean density were significantly lower in patients with myopia up to -6.0 D compared to the healthy individuals.
METHODS: A total of 80 male individuals aged 18-20 years were included in the study with 40 moderate myopic and 40 healthy persons. All participants underwent detailed ocular examination including refraction, intraocular pressure (IOP), visual acuity, biomicroscopy, OCTA measurement and optic biometry measurement. Retinal, retinal nerve fiber layer and choroidal layer thicknesses were evaluated in µm with the help of the software available in the OCTA device.
RESULTS: The mean axial length (24.32 ± 0.53 mm) was statistically significantly higher in the moderate myopic group (24.32 mm) compared to the healthy group (23.33 ± 0.61 mm) (p < 0.001). Spherical equivalent (SE) was found as -3.79 ± 0.91 D in the moderate myopic group and -0.22 ± 0.32 D in the healthy group (p < 0.05). The mean superficial foveal mean density (FovSupMVD) and the mean deep foveal mean density (FovDepMVD) were statistically significantly lower in the moderate myopic group than in the healthy group (both, p < 0.001). The mean retinal temporal thickness (RTt) was statistically significantly lower in the moderate myopic group (p = 0.017). There was a mild negative correlation between axial length and FovSupMVD, FovDepMVD in myopes. In axial length ROC analysis, the cutoff value for moderate myopes was found to be 24.15 mm. Mean superficial foveal mean density (FovSupMVD) and mean deep foveal mean density (FovDepMVD), mean retinal temporal thickness (RTt) were significantly lower in the group above 24.15 mm axial length compared to the group below 24.15 mm axial length (all three, p < 0.001). Foveal avascular zone was significantly higher in the group above 24.15 mm axial length (p = 0.016) CONCLUSION: The results of our study indicate that the mean axial length and spherical equivalent were significantly higher, while retinal temporal thickness, the mean superficial foveal mean density and the mean deep foveal mean density were significantly lower in patients with myopia up to -6.0 D compared to the healthy individuals.
摘要：
目的：本研究的目的是回顾性评估和比较中度近视患者和健康个体的光学相干断层扫描血管造影（OCTA）参数。
方法：共纳入80名18-20岁男性个体，40名中度近视者和40名健康人。所有参与者都接受了详细的眼部检查，包括屈光，眼内压（IOP），视敏度,生物显微镜,OCTA测量和光学生物测量。视网膜，视网膜神经纤维层和脉络膜层厚度借助OCTA装置中的软件以µm为单位进行评估.
结果：中度近视组（24.32mm）的平均眼轴长度（24.32mm±0.53mm）明显高于健康组（23.33mm±0.61mm）（p<0.001）。中度近视组球当量（SE）为-3.79±0.91D，健康组为-0.22±0.32D（p<0.05）。中度近视组的平均浅凹平均密度（FovSupMVD）和平均深凹平均密度（FovDepMVD）在统计学上显着低于健康组（两者，p<0.001)。中度近视组的平均视网膜颞叶厚度（RTt）在统计学上显着降低（p=0.017）。轴向长度与FovSupMVD之间存在轻度负相关，在近视中的FovDepMVD。在轴向长度ROC分析中，中度近视的临界值为24.15毫米。平均浅中央凹平均密度（FovSupMVD）和平均深中央凹平均密度（FovDepMVD），眼轴长度高于24.15mm的组的平均视网膜颞叶厚度(RTt)显著低于眼轴长度低于24.15mm的组(所有三个,p<0.001)。在24.15mm轴向长度以上的组中，中央凹无血管区明显更高（p=0.016）结论：我们的研究结果表明，平均轴向长度和等效球形明显更高，而视网膜颞部厚度，与健康个体相比，近视患者在-6.0D以下的平均浅凹平均密度和平均深凹平均密度均显着降低。
方法：共纳入80名18-20岁男性个体，40名中度近视者和40名健康人。所有参与者都接受了详细的眼部检查，包括屈光，眼内压（IOP），视敏度,生物显微镜,OCTA测量和光学生物测量。视网膜，视网膜神经纤维层和脉络膜层厚度借助OCTA装置中的软件以µm为单位进行评估.
结果：中度近视组（24.32mm）的平均眼轴长度（24.32mm±0.53mm）明显高于健康组（23.33mm±0.61mm）（p<0.001）。中度近视组球当量（SE）为-3.79±0.91D，健康组为-0.22±0.32D（p<0.05）。中度近视组的平均浅凹平均密度（FovSupMVD）和平均深凹平均密度（FovDepMVD）在统计学上显着低于健康组（两者，p<0.001)。中度近视组的平均视网膜颞叶厚度（RTt）在统计学上显着降低（p=0.017）。轴向长度与FovSupMVD之间存在轻度负相关，在近视中的FovDepMVD。在轴向长度ROC分析中，中度近视的临界值为24.15毫米。平均浅中央凹平均密度（FovSupMVD）和平均深中央凹平均密度（FovDepMVD），眼轴长度高于24.15mm的组的平均视网膜颞叶厚度(RTt)显著低于眼轴长度低于24.15mm的组(所有三个,p<0.001)。在24.15mm轴向长度以上的组中，中央凹无血管区明显更高（p=0.016）结论：我们的研究结果表明，平均轴向长度和等效球形明显更高，而视网膜颞部厚度，与健康个体相比，近视患者在-6.0D以下的平均浅凹平均密度和平均深凹平均密度均显着降低。
