PDF(Pubmed)
Abstract：
Infection with Strongyloides stercoralis is often asymptomatic but can be life-threatening in immunocompromised patients, which can be prevented by ivermectin (IVM) treatment. The efficacy of IVM has been reported to have lessened over time in some regions as a consequence of prolonged use and mass treatment campaigns. Ivermectin has been used in Thailand for more than a decade; therefore, we investigated the efficacy of a single dose (200 µg/kg) of IVM against in asymptomatic strongyloidiasis in northeastern Thailand. Fecal samples were collected before and 2 weeks after treatment and were analyzed for the presence of Strongyloides using a modified agar plate culture and the formalin-ethyl acetate concentration technique. Our results showed that single-dose IVM treatment successfully eliminated S. stercoralis infection in asymptomatic individuals in the endemic area with a 100% cure rate, indicating the high efficacy of IVM treatment in strongyloidiasis in northeast Thailand.
摘要：
在免疫功能低下的患者中，胸圆线虫感染通常无症状，但可能危及生命。伊维菌素（IVM）治疗可以预防。据报道，由于长期使用和大规模治疗运动，随着时间的推移，一些地区的病媒综合防治的疗效有所下降。伊维菌素已经在泰国使用了十多年；因此，我们在泰国东北部研究了单剂量(200μg/kg)IVM对无症状性圆线虫病的疗效.在处理前和处理后2周收集粪便样品，并使用改良的琼脂平板培养物和福尔马林-乙酸乙酯浓缩技术分析类圆线虫的存在。我们的结果表明，单剂量IVM治疗成功消除了无症状个体中的胸骨链球菌感染，治愈率为100％，表明IVM治疗泰国东北部圆线虫病的高疗效。
