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Abstract：
BACKGROUND: Although chronic erosive gastritis (CEG) is common, its clinical characteristics have not been fully elucidated. The lack of consensus regarding its treatment has resulted in varied treatment regimens.
OBJECTIVE: To explore the clinical characteristics, treatment patterns, and short-term outcomes in CEG patients in China.
METHODS: We recruited patients with chronic non-atrophic or mild-to-moderate atrophic gastritis with erosion based on endoscopy and pathology. Patients and treating physicians completed a questionnaire regarding history, endoscopic findings, and treatment plans as well as a follow-up questionnaire to investigate changes in symptoms after 4 wk of treatment.
RESULTS: Three thousand five hundred sixty-three patients from 42 centers across 24 cities in China were included. Epigastric pain (68.0%), abdominal distension (62.6%), and postprandial fullness (47.5%) were the most common presenting symptoms. Gastritis was classified as chronic non-atrophic in 69.9% of patients. Among those with erosive lesions, 72.1% of patients had lesions in the antrum, 51.0% had multiple lesions, and 67.3% had superficial flat lesions. In patients with epigastric pain, the combination of a mucosal protective agent (MPA) and proton pump inhibitor was more effective. For those with postprandial fullness, acid regurgitation, early satiety, or nausea, a MPA appeared more promising.
CONCLUSIONS: CEG is a multifactorial disease which is common in Asian patients and has non-specific symptoms. Gastroscopy may play a major role in its detection and diagnosis. Treatment should be individualized based on symptom profile.
OBJECTIVE: To explore the clinical characteristics, treatment patterns, and short-term outcomes in CEG patients in China.
METHODS: We recruited patients with chronic non-atrophic or mild-to-moderate atrophic gastritis with erosion based on endoscopy and pathology. Patients and treating physicians completed a questionnaire regarding history, endoscopic findings, and treatment plans as well as a follow-up questionnaire to investigate changes in symptoms after 4 wk of treatment.
RESULTS: Three thousand five hundred sixty-three patients from 42 centers across 24 cities in China were included. Epigastric pain (68.0%), abdominal distension (62.6%), and postprandial fullness (47.5%) were the most common presenting symptoms. Gastritis was classified as chronic non-atrophic in 69.9% of patients. Among those with erosive lesions, 72.1% of patients had lesions in the antrum, 51.0% had multiple lesions, and 67.3% had superficial flat lesions. In patients with epigastric pain, the combination of a mucosal protective agent (MPA) and proton pump inhibitor was more effective. For those with postprandial fullness, acid regurgitation, early satiety, or nausea, a MPA appeared more promising.
CONCLUSIONS: CEG is a multifactorial disease which is common in Asian patients and has non-specific symptoms. Gastroscopy may play a major role in its detection and diagnosis. Treatment should be individualized based on symptom profile.
摘要：
背景：尽管慢性糜烂性胃炎（CEG）很常见，其临床特征尚未完全阐明。对其治疗缺乏共识导致不同的治疗方案。
目的：探讨临床特点，治疗模式,中国CEG患者的短期结局。
方法：我们招募了慢性非萎缩性或轻中度萎缩性胃炎伴糜烂的患者。患者和治疗医生填写了一份关于病史的问卷，内镜检查结果,和治疗计划以及随访问卷，以调查治疗4周后症状的变化。
结果：纳入了来自中国24个城市42个中心的三千五百六十三名患者。上腹痛（68.0％），腹胀(62.6%),餐后饱胀（47.5％）是最常见的症状。69.9％的患者将胃炎分类为慢性非萎缩性。在那些有糜烂性病变的人中，72.1%的患者胃窦有病变,51.0%有多个病灶,67.3%为浅表平坦病变。在上腹痛患者中，粘膜保护剂(MPA)和质子泵抑制剂的组合更有效.对于那些餐后饱腹感的人，酸反流,早期饱腹感,或者恶心,MPA似乎更有希望。
结论：CEG是一种多因素疾病，常见于亚洲患者，具有非特异性症状。胃镜检查可能在其检测和诊断中起主要作用。治疗应根据症状情况进行个体化。
目的：探讨临床特点，治疗模式,中国CEG患者的短期结局。
方法：我们招募了慢性非萎缩性或轻中度萎缩性胃炎伴糜烂的患者。患者和治疗医生填写了一份关于病史的问卷，内镜检查结果,和治疗计划以及随访问卷，以调查治疗4周后症状的变化。
结果：纳入了来自中国24个城市42个中心的三千五百六十三名患者。上腹痛（68.0％），腹胀(62.6%),餐后饱胀（47.5％）是最常见的症状。69.9％的患者将胃炎分类为慢性非萎缩性。在那些有糜烂性病变的人中，72.1%的患者胃窦有病变,51.0%有多个病灶,67.3%为浅表平坦病变。在上腹痛患者中，粘膜保护剂(MPA)和质子泵抑制剂的组合更有效.对于那些餐后饱腹感的人，酸反流,早期饱腹感,或者恶心,MPA似乎更有希望。
结论：CEG是一种多因素疾病，常见于亚洲患者，具有非特异性症状。胃镜检查可能在其检测和诊断中起主要作用。治疗应根据症状情况进行个体化。
