Abstract：
Thalassemia major is one of the health problems in Iraq, especially in Kurdistan. Pre-marriage mandatory preventive screening program was established in Kurdistan in 2008, which allowed us to study the prevalence of different hemoglobinopathies among newly married young adults in this region. A total of 1154 subjects (577 couples) attending the Koya district, premarital Health center, were screened using red cell indices. Those who had mean corpuscular volume (MCV)<80 fl and mean corpuscular hemoglobin (MCH)<27 pg had high-performance liquid chromatography and iron studies. Out of 1154 individuals that were evaluated, 183 (11.9%) had low MCV and MCH. Of the former 183 subjects, 69 (5.97%) had β-thalassemia trait, 10 (0.86%) had δβ-thalassemia trait, and no other hemoglobinopathies were recorded in our study. There was second-degree consanguinity in 4.7% of all 577 couples. In two couples, both partners had β-thalassemia trait and both were consanguineous. Both couples decided to separate after counseling. Based on the current study, the role of the premarital screening program in decreasing the number of new thalassemia major cases among the Kurdish population is laudable. Therefore, mandatory premarital screening is advised in all parts of Iraq.
摘要：
地中海贫血是伊拉克的健康问题之一，尤其是在库尔德斯坦.2008年在库尔德斯坦建立了婚前强制性预防性筛查计划，这使我们能够研究该地区新婚年轻人中不同血红蛋白病的患病率。共有1154名受试者(577对夫妇)参加科亚区，婚前保健中心,使用红细胞指数进行筛选。那些平均红细胞体积（MCV）<80fl且平均红细胞血红蛋白（MCH）<27pg的人进行了高效液相色谱和铁研究。在接受评估的1154人中，183（11.9%）的MCV和MCH较低。在前183个科目中，69（5.97%）具有β地中海贫血性状，10人（0.86%）具有δβ地中海贫血性状，在我们的研究中没有记录到其他血红蛋白病。在所有577对夫妇中，有4.7％的人有二级血缘关系。在两对夫妇中，两个伴侣都有β-地中海贫血特征，并且都是近亲。两对夫妇在咨询后决定分开。根据目前的研究,婚前筛查计划在减少库尔德人人群中新增地中海贫血主要病例数量方面的作用值得称赞.因此,建议在伊拉克各地进行强制性婚前筛查。
