Abstract：
This study focused on the link between skin disorders and Methylenetetrahydrofolate reductase (MTHFR) polymorphisms.
Study cases were taken from a pre-conceptional care program where patients with poor obstetric history were evaluated in terms of systemic disorders including skin diseases. This retrospective cohort (n = 472) consisted of 110 (23.3%) and 362 (76.7%) women with or without skin disorders, respectively. For ease of analysis, the history of skin diseases was classified into seven categories: (1) acne/rosacea/other acneiform disorders; (2) fungal disease; (3) pruritis/xerosis; (4) psoriasis vulgaris; (5) acrochordons and other benign skin growths; (6) urticaria/dermatitis; and (7) viral diseases.
In this retrospective cohort of 472 women, we explored the impact of MTHFR A1298C and C677T polymorphisms on skin disorders. Despite similar allelic frequencies, our findings revealed a statistically significant association between the presence of MTHFR polymorphisms and skin disorders (p = .027). Subgroup analysis indicated significantly higher rates of MTHFR polymorphisms in patients with psoriasis vulgaris (p = .033) and acrochordons (p = .030), highlighting their potential relevance in specific skin disorder subtypes.
The increased prevalence of psoriasis and acrochordons among women with MTHFR deficiency underscores the complex relationship between genetic factors and dermatological health. Our findings emphasized the critical role of MTHFR polymorphisms not only in poor obstetric history but also as significant contributors to skin disorders. This dual association highlights the importance of comprehensive preconception counseling, especially customized for women affected by skin disorders.
Study cases were taken from a pre-conceptional care program where patients with poor obstetric history were evaluated in terms of systemic disorders including skin diseases. This retrospective cohort (n = 472) consisted of 110 (23.3%) and 362 (76.7%) women with or without skin disorders, respectively. For ease of analysis, the history of skin diseases was classified into seven categories: (1) acne/rosacea/other acneiform disorders; (2) fungal disease; (3) pruritis/xerosis; (4) psoriasis vulgaris; (5) acrochordons and other benign skin growths; (6) urticaria/dermatitis; and (7) viral diseases.
In this retrospective cohort of 472 women, we explored the impact of MTHFR A1298C and C677T polymorphisms on skin disorders. Despite similar allelic frequencies, our findings revealed a statistically significant association between the presence of MTHFR polymorphisms and skin disorders (p = .027). Subgroup analysis indicated significantly higher rates of MTHFR polymorphisms in patients with psoriasis vulgaris (p = .033) and acrochordons (p = .030), highlighting their potential relevance in specific skin disorder subtypes.
The increased prevalence of psoriasis and acrochordons among women with MTHFR deficiency underscores the complex relationship between genetic factors and dermatological health. Our findings emphasized the critical role of MTHFR polymorphisms not only in poor obstetric history but also as significant contributors to skin disorders. This dual association highlights the importance of comprehensive preconception counseling, especially customized for women affected by skin disorders.
摘要：
■本研究集中于皮肤病与亚甲基四氢叶酸还原酶（MTHFR）多态性之间的联系。
研究病例来自一个孕前护理计划，在该计划中，对产科病史不良的患者进行了包括皮肤病在内的全身性疾病评估。这项回顾性队列（n=472）由110名（23.3％）和362名（76.7％）患有或不患有皮肤病的女性组成。分别。为了便于分析，皮肤病的病史分为七类:1)痤疮/酒渣鼻/其他痤疮样疾病;2)真菌病;3)瘙痒/干燥病;4)寻常型银屑病;5)肩索和其他良性皮肤生长;6)荨麻疹/皮炎;和7)病毒性疾病。
■在这个由472名女性组成的回顾性队列中，我们探讨了MTHFRA1298C和C677T多态性对皮肤病的影响。尽管等位基因频率相似，我们的发现揭示了MTHFR多态性的存在与皮肤病之间的统计学显著关联(p=0.027).亚组分析表明，寻常型银屑病患者（p=0.033）和顶索患者（p=0.030）的MTHFR多态性发生率明显更高，强调它们在特定皮肤病亚型中的潜在相关性。
■在患有MTHFR缺乏症的女性中，银屑病和顶索的患病率增加强调了遗传因素与皮肤健康之间的复杂关系。我们的发现强调了MTHFR多态性不仅在不良产科病史中的关键作用，而且是皮肤病的重要贡献者。这种双重关联凸显了全面的先入为主咨询的重要性,特别是为受皮肤病影响的女性定制。
研究病例来自一个孕前护理计划，在该计划中，对产科病史不良的患者进行了包括皮肤病在内的全身性疾病评估。这项回顾性队列（n=472）由110名（23.3％）和362名（76.7％）患有或不患有皮肤病的女性组成。分别。为了便于分析，皮肤病的病史分为七类:1)痤疮/酒渣鼻/其他痤疮样疾病;2)真菌病;3)瘙痒/干燥病;4)寻常型银屑病;5)肩索和其他良性皮肤生长;6)荨麻疹/皮炎;和7)病毒性疾病。
■在这个由472名女性组成的回顾性队列中，我们探讨了MTHFRA1298C和C677T多态性对皮肤病的影响。尽管等位基因频率相似，我们的发现揭示了MTHFR多态性的存在与皮肤病之间的统计学显著关联(p=0.027).亚组分析表明，寻常型银屑病患者（p=0.033）和顶索患者（p=0.030）的MTHFR多态性发生率明显更高，强调它们在特定皮肤病亚型中的潜在相关性。
■在患有MTHFR缺乏症的女性中，银屑病和顶索的患病率增加强调了遗传因素与皮肤健康之间的复杂关系。我们的发现强调了MTHFR多态性不仅在不良产科病史中的关键作用，而且是皮肤病的重要贡献者。这种双重关联凸显了全面的先入为主咨询的重要性,特别是为受皮肤病影响的女性定制。
