Abstract：
Phytochemical investigation of the trunks from Gnetum latifolium led to the isolation of a novel phenolic glucoside, 2E-2,4-di-(3,4-dihydroxyphenyl)but-2-en-1-yl-O-β-D-glucopyranoside (1), along with five known stilbene derivatives (2-6). Their structures were determined mainly using high-resolution electrospray ionisation mass spectrometry and nuclear magnetic resonance spectroscopic analyses, followed by comparisons of observed spectral data with reported values. The novel compound 1 in G. latifolium was found to be useful as a chemotaxonomic marker. Biological evaluation revealed that compound 6 had remarkable inhibitory effects on nitric oxide production, with a half-maximal inhibitory concentration (IC50) value of 4.85 ± 0.20 µM, which was much higher than that of the positive control dexamethasone (IC50 = 14.20 ± 0.54 µM).
摘要：
对Gnetumlatifolium树干的植物化学研究导致了一种新型的酚类葡萄糖苷的分离，2E-2,4-二-(3,4-二羟基苯基)丁-2-烯-1-基-O-β-D-吡喃葡萄糖苷(1),以及五种已知的二苯乙烯衍生物(2-6)。它们的结构主要使用高分辨率电喷雾电离质谱和核磁共振光谱分析来确定，然后将观察到的光谱数据与报告值进行比较。发现G.latifolium中的新型化合物1可用作化学分类学标记。生物学评价显示化合物6对一氧化氮的产生有显著的抑制作用,半最大抑制浓度（IC50）值为4.85±0.20µM，远高于阳性对照地塞米松（IC50=14.20±0.54µM）。
