{Reference Type}: Journal Article
{Title}: Identification and nitric oxide production inhibitory activity of phenolic derivatives from the trunks of Gnetum latifolium.
{Author}: Hoa NTT;Cham BT;Hoang Anh NT;Tuan Hiep N;Anh NTK;Nhung LTH;Adorisio S;Delfino DV;Thuy TT;Thuy Linh NT;
{Journal}: Nat Prod Res
{Volume}: 0
{Issue}: 0
{Year}: 2024 Feb 23
{Factor}: 2.488
{DOI}: 10.1080/14786419.2024.2320729
{Abstract}: Phytochemical investigation of the trunks from Gnetum latifolium led to the isolation of a novel phenolic glucoside, 2E-2,4-di-(3,4-dihydroxyphenyl)but-2-en-1-yl-O-β-D-glucopyranoside (1), along with five known stilbene derivatives (2-6). Their structures were determined mainly using high-resolution electrospray ionisation mass spectrometry and nuclear magnetic resonance spectroscopic analyses, followed by comparisons of observed spectral data with reported values. The novel compound 1 in G. latifolium was found to be useful as a chemotaxonomic marker. Biological evaluation revealed that compound 6 had remarkable inhibitory effects on nitric oxide production, with a half-maximal inhibitory concentration (IC50) value of 4.85 ± 0.20 µM, which was much higher than that of the positive control dexamethasone (IC50 = 14.20 ± 0.54 µM).