24种芳香族化合物,包括5种新型化合物,多利abphenosidesA(1),B1(2)、B2(3)、C1(4),和C2(5)是从DolichoslablabL的种子中获得的。它们的结构是基于光谱分析和化学反应建立的。在已知的化合物中,第一次从豆科获得了9、10、14、17、19和22-24,和6、8、11-13、15、16、18、20以及21个首先从Dolichos属中鉴定。此外,在RAW264.7巨噬细胞中,所有分离物对LPS诱导的一氧化氮(NO)产生的抑制作用评估表明,化合物1-3、6、7、11-15、17、20、21、23、24以浓度依赖性方式表现出抗炎活性。此外,新的化合物,多利abphenosidesA(1),B1(2)、发现B2(3)抑制炎性细胞因子IL-1β的分泌。
Twenty-four aromatic compounds including five novel ones, dolilabphenosides A (1), B1 (2), B2 (3), C1 (4), and C2 (5) were obtained from the seeds of Dolichos lablab L. Their structures were established based on spectroscopic analyses and chemical reactions. Among the known compounds, 9, 10, 14, 17, 19, and 22-24 were gained from the family Leguminosae for the first time, and 6, 8, 11-13, 15, 16, 18, 20, as well as 21 were firstly identified from Dolichos genus. Moreover, the inhibitory effect evaluation of all the isolates against LPS-induced nitric oxide (NO) production in RAW264.7 macrophages suggested that compounds 1-3, 6, 7, 11-15, 17, 20, 21, 23, 24 exhibited anti-inflammatory activity in a concentration-dependent manner. Moreover, the novel compounds, dolilabphenosides A (1), B1 (2), B2 (3) were found to inhibit the secretion of inflammatory cytokine IL-1β.