Abstract：
OBJECTIVE: South Asia remains home to foodborne diseases caused by the Vibrio species. We aimed to compile and update information on the epidemiology of vibriosis in South Asia.
METHODS: For this systematic review and meta-analysis, we searched PubMed, Web of Science, EMBASE, and Google Scholar for studies related to vibriosis in South Asia published up to May 2023. A random-effects meta-analysis was used to estimate the pooled isolation rate of non-cholera-causing Vibrio species.
RESULTS: In total, 38 studies were included. Seven of these were case reports and 22 were included in the meta-analysis. The reported vibriosis cases were caused by non-O1/non-O139 V. cholerae, V. parahaemolyticus, V. fluvialis, and V. vulnificus. The overall pooled isolation rate was 4.0% (95% confidence interval [CI] 3.0-5.0%) in patients with diarrhea. Heterogeneity was high (I2 = 98.0%). The isolation rate of non-O1/non-O139 V. cholerae, V. parahaemolyticus, and V. fluvialis were 9.0 (95% CI 7.0-10.0%), 1.0 (95% CI 1.0-2.0%), and 2.0 (95% CI: 1.0-3.0%), respectively. Regarding V. parahaemolyticus, O3:K6 was the most frequently isolated serotype. Cases peaked during summer. Several studies reported antibiotic-resistant strains and those harboring extended-spectrum beta-lactamases genes.
CONCLUSIONS: This study demonstrates a high burden of infections caused by non-cholera-causing Vibrio species in South Asia.
METHODS: For this systematic review and meta-analysis, we searched PubMed, Web of Science, EMBASE, and Google Scholar for studies related to vibriosis in South Asia published up to May 2023. A random-effects meta-analysis was used to estimate the pooled isolation rate of non-cholera-causing Vibrio species.
RESULTS: In total, 38 studies were included. Seven of these were case reports and 22 were included in the meta-analysis. The reported vibriosis cases were caused by non-O1/non-O139 V. cholerae, V. parahaemolyticus, V. fluvialis, and V. vulnificus. The overall pooled isolation rate was 4.0% (95% confidence interval [CI] 3.0-5.0%) in patients with diarrhea. Heterogeneity was high (I2 = 98.0%). The isolation rate of non-O1/non-O139 V. cholerae, V. parahaemolyticus, and V. fluvialis were 9.0 (95% CI 7.0-10.0%), 1.0 (95% CI 1.0-2.0%), and 2.0 (95% CI: 1.0-3.0%), respectively. Regarding V. parahaemolyticus, O3:K6 was the most frequently isolated serotype. Cases peaked during summer. Several studies reported antibiotic-resistant strains and those harboring extended-spectrum beta-lactamases genes.
CONCLUSIONS: This study demonstrates a high burden of infections caused by non-cholera-causing Vibrio species in South Asia.
摘要：
背景：南亚仍然是由弧菌引起的食源性疾病的家园。我们旨在收集和更新有关南亚弧菌病流行病学的信息。
方法：对于本系统综述和荟萃分析，我们搜索了PubMed,WebofScience,EMBASE,以及截至2023年5月发表的南亚弧菌病相关研究的谷歌学者。使用随机效应荟萃分析来估计非霍乱引起的弧菌物种的合并分离率。
结果：共纳入38项研究。其中7例是病例报告，22例纳入荟萃分析。报告的弧菌病病例由非O1/非O139霍乱弧菌引起，五、副溶血病，V.Fluvialis,和V.创伤。腹泻患者的总体合并隔离率为4.0％（95％CI：3.0-5.0％）。异质性高(I2=98.0%)。非O1/非O139霍乱弧菌的分离率，五、副溶血病，流静脉为9.0（95％CI：7.0-10.0％），1.0（95%CI：1.0-2.0%），和2.0（95%CI：1.0-3.0%），分别。关于副溶血性弧菌，O3:K6是最常见的分离血清型。病例在夏季达到高峰。一些研究报告了抗生素抗性菌株和那些具有超广谱β-内酰胺酶基因的菌株。
结论：这项研究表明，在南亚，由非霍乱引起的弧菌引起的感染负担很高。
方法：对于本系统综述和荟萃分析，我们搜索了PubMed,WebofScience,EMBASE,以及截至2023年5月发表的南亚弧菌病相关研究的谷歌学者。使用随机效应荟萃分析来估计非霍乱引起的弧菌物种的合并分离率。
结果：共纳入38项研究。其中7例是病例报告，22例纳入荟萃分析。报告的弧菌病病例由非O1/非O139霍乱弧菌引起，五、副溶血病，V.Fluvialis,和V.创伤。腹泻患者的总体合并隔离率为4.0％（95％CI：3.0-5.0％）。异质性高(I2=98.0%)。非O1/非O139霍乱弧菌的分离率，五、副溶血病，流静脉为9.0（95％CI：7.0-10.0％），1.0（95%CI：1.0-2.0%），和2.0（95%CI：1.0-3.0%），分别。关于副溶血性弧菌，O3:K6是最常见的分离血清型。病例在夏季达到高峰。一些研究报告了抗生素抗性菌株和那些具有超广谱β-内酰胺酶基因的菌株。
结论：这项研究表明，在南亚，由非霍乱引起的弧菌引起的感染负担很高。
