%0 Meta-Analysis
%T Vibriosis in South Asia: A systematic review and meta-analysis.
%A Muzembo BA
%A Kitahara K
%A Ohno A
%A Khatiwada J
%A Dutta S
%A Miyoshi SI
%J Int J Infect Dis
%V 141
%N 0
%D 2024 Apr 2
%M 38311027
%F 12.074
%R 10.1016/j.ijid.2024.01.022
%X <B>OBJECTIVE: </B>South Asia remains home to foodborne diseases caused by the Vibrio species. We aimed to compile and update information on the epidemiology of vibriosis in South Asia.<BR><B>METHODS: </B>For this systematic review and meta-analysis, we searched PubMed, Web of Science, EMBASE, and Google Scholar for studies related to vibriosis in South Asia published up to May 2023. A random-effects meta-analysis was used to estimate the pooled isolation rate of non-cholera-causing Vibrio species.<BR><B>RESULTS: </B>In total, 38 studies were included. Seven of these were case reports and 22 were included in the meta-analysis. The reported vibriosis cases were caused by non-O1/non-O139 V. cholerae, V. parahaemolyticus, V. fluvialis, and V. vulnificus. The overall pooled isolation rate was 4.0% (95% confidence interval [CI] 3.0-5.0%) in patients with diarrhea. Heterogeneity was high (I2 = 98.0%). The isolation rate of non-O1/non-O139 V. cholerae, V. parahaemolyticus, and V. fluvialis were 9.0 (95% CI 7.0-10.0%), 1.0 (95% CI 1.0-2.0%), and 2.0 (95% CI: 1.0-3.0%), respectively. Regarding V. parahaemolyticus, O3:K6 was the most frequently isolated serotype. Cases peaked during summer. Several studies reported antibiotic-resistant strains and those harboring extended-spectrum beta-lactamases genes.<BR><B>CONCLUSIONS: </B>This study demonstrates a high burden of infections caused by non-cholera-causing Vibrio species in South Asia.