Abstract：
UNASSIGNED: The introduction of low titer group O whole blood (LTOWB) that contains potentially ABO-incompatible plasma and the increasing use of group A plasma, due to shortages of AB plasma, in trauma patients whose ABO group is unknown could put the recipients of incompatible plasma at risk of increased morbidity and mortality. This study evaluated civilian trauma patient outcomes following receipt of incompatible plasma.
UNASSIGNED: One trauma center\'s patient contributions to three multicenter studies of different trauma resuscitation strategies was analyzed; these patients were separated into two groups based on receipt of only compatible plasma versus receipt of any quantity of incompatible plasma. Multivariate analysis was performed to determine if receipt of incompatible plasma was associated with 24-hour or 30-day mortality.
UNASSIGNED: There were 347 patients eligible for this secondary analysis with 167 recipients of only compatible plasma and 180 recipients of incompatible plasma. The two groups were well matched demographically and on both prehospital and hospital arrival vital signs. The median (IQR) volume of incompatible plasma received by these patients was 684 ml (342, 1229). There was not a significant difference between the groups in 24-hour and 30-day mortality, nor in in-hospital or intensive care unit lengths of stay. In the Cox proportional-hazards regression model for both 24-hour and 30-day survival, receipt of incompatible plasma was not independently predictive of either mortality endpoint.
UNASSIGNED: Receipt of incompatible plasma was not independently associated with increased mortality in trauma patients. Prospective studies are needed to confirm these findings.
UNASSIGNED: One trauma center\'s patient contributions to three multicenter studies of different trauma resuscitation strategies was analyzed; these patients were separated into two groups based on receipt of only compatible plasma versus receipt of any quantity of incompatible plasma. Multivariate analysis was performed to determine if receipt of incompatible plasma was associated with 24-hour or 30-day mortality.
UNASSIGNED: There were 347 patients eligible for this secondary analysis with 167 recipients of only compatible plasma and 180 recipients of incompatible plasma. The two groups were well matched demographically and on both prehospital and hospital arrival vital signs. The median (IQR) volume of incompatible plasma received by these patients was 684 ml (342, 1229). There was not a significant difference between the groups in 24-hour and 30-day mortality, nor in in-hospital or intensive care unit lengths of stay. In the Cox proportional-hazards regression model for both 24-hour and 30-day survival, receipt of incompatible plasma was not independently predictive of either mortality endpoint.
UNASSIGNED: Receipt of incompatible plasma was not independently associated with increased mortality in trauma patients. Prospective studies are needed to confirm these findings.
摘要：
■引入含有潜在ABO不相容血浆的低滴度O组全血（LTOWB），以及增加使用A组血浆，由于AB等离子体的短缺，在ABO组未知的创伤患者中,不相容血浆受体有增加发病率和死亡率的风险.这项研究评估了接受不相容血浆后的平民创伤患者的预后。
■分析了一个创伤中心的患者对三项不同创伤复苏策略的多中心研究的贡献；根据仅接受相容血浆与接受任何量的不相容血浆，将这些患者分为两组。进行多变量分析以确定接受不相容血浆是否与24小时或30天死亡率相关。
■有347名患者符合此二次分析的条件，其中167名仅接受相容血浆，180名接受不相容血浆。两组在人口统计上以及院前和医院到达的生命体征上都很匹配。这些患者接受的不相容血浆的中位数（IQR）体积为684ml（342，1229）。两组在24小时和30天死亡率方面没有显着差异，也没有在医院或重症监护病房住院时间。在24小时和30天生存的Cox比例风险回归模型中，接受不相容血浆不能独立预测任一死亡终点.
■接受不相容血浆与创伤患者死亡率增加并不独立相关。需要前瞻性研究来证实这些发现。
■分析了一个创伤中心的患者对三项不同创伤复苏策略的多中心研究的贡献；根据仅接受相容血浆与接受任何量的不相容血浆，将这些患者分为两组。进行多变量分析以确定接受不相容血浆是否与24小时或30天死亡率相关。
■有347名患者符合此二次分析的条件，其中167名仅接受相容血浆，180名接受不相容血浆。两组在人口统计上以及院前和医院到达的生命体征上都很匹配。这些患者接受的不相容血浆的中位数（IQR）体积为684ml（342，1229）。两组在24小时和30天死亡率方面没有显着差异，也没有在医院或重症监护病房住院时间。在24小时和30天生存的Cox比例风险回归模型中，接受不相容血浆不能独立预测任一死亡终点.
■接受不相容血浆与创伤患者死亡率增加并不独立相关。需要前瞻性研究来证实这些发现。
