背景:这项研究确定了2017年至2022年加纳一家地区医院献血者中输血传播感染(TTI)的趋势。
方法:对6339份献血者记录进行回顾性分析。使用STATA17.0版以0.05显著性水平分析数据。
结果:2017年的TTI患病率为31.4%,2018年为13.8%,2019年为20.4%,2020年为9.5%,2021年为9.6%,2022年为11.7%。丙型肝炎病毒(HCV),梅毒,和性别(OR=2.06;95%CI[1.29-3.30];P=.003)和(OR=2.28;95%CI[1.48-3.54];P<.001),分别。20-29岁的献血者更容易感染乙型肝炎病毒(OR=1.96;95%CI[1.28-2.99];P=0.002)。40-49岁的献血者感染HCV(OR=3.36;95%CI[2.02-5.57];P<.001)和梅毒(OR=3.79;95%CI[2.45-5.87];P<.001)的几率更高。
结论:该研究强调需要对TTI患病率较高的捐献者实施有针对性的预防策略。
加纳地区医院献血者的输血传播感染趋势:2017年至2022年背景尽管努力提高血液供应的安全性,输血传播感染(TTI)仍然是一个严重的问题。这项研究确定了2017年至2022年加纳地区医院献血者中TTI的趋势。方法对6339例献血者的记录进行回顾性分析,以确定是否存在抗人类免疫缺陷病毒1/2IgG/IgM。乙型肝炎病毒(HBV),抗丙型肝炎病毒(HCV)IgG/IgM,和抗梅毒螺旋体IgG/IgM/IgA。使用STATA17.0版分析数据。描述性和推断性统计学均以0.05的显著性水平使用。6339名献血者的结果,16.1%显示至少一个TTI的血清学证据。趋势分析显示,2017年的TTI患病率为31.4%,2018年为13.8%,2019年为20.4%,2020年下降至9.5%,2021年为9.6%,2022年上升至11.7%。与女性献血者相比,TTI在男性献血者中占主导地位。HCV之间存在显着关联,梅毒,和性别(aOR=2.06;95%CI[0.59-1.73];P=0.003)和(aOR=2.28;95%CI[0.15-0.69];P<.001)。20至29岁的捐赠者更有可能感染HBV(aOR=1.96;95CI[1.28-2.99];P=0.002)。此外,40~49岁的供者更容易感染HCV和梅毒(aOR=3.36;95%CI[2.02-5.57];P<.001)和(aOR=3.79;95%CI[2.45-5.87];P<.001).结论该研究确定了TTI的总体患病率很高,强调需要鼓励女性捐助者参与,提高年轻人对安全做法的认识,并对TTI患病率较高的男性实施有针对性的预防策略。
BACKGROUND: This study determined the trends of transfusion-transmissible infections (TTIs) among blood donors in a regional hospital in Ghana from 2017 to 2022.
METHODS: A retrospective analysis was conducted on 6339 blood donor records. Data were analyzed using STATA version 17.0 at the 0.05 significance level.
RESULTS: The prevalence of TTIs was 31.4% in 2017, 13.8% in 2018, 20.4% in 2019, 9.5% in 2020, 9.6% in 2021, and 11.7% in 2022. There were significant associations between hepatitis C virus (HCV), Syphilis, and sex (OR = 2.06; 95% CI [1.29-3.30]; P = .003) and (OR = 2.28; 95% CI [1.48-3.54]; P < .001), respectively. Blood donors aged 20-29 were more likely to be infected with hepatitis B virus (OR = 1.96; 95% CI [1.28-2.99]; P = .002). Blood donors aged 40-49 had higher odds of infection with HCV (OR = 3.36; 95% CI [2.02-5.57]; P < .001) and Syphilis (OR = 3.79; 95% CI [2.45-5.87]; P < .001).
CONCLUSIONS: The study highlights the need to implement targeted prevention strategies for donors with a higher TTI prevalence.
Trends in transfusion-transmissible infections among blood donors in a Regional Hospital in Ghana: 2017 to 2022BackgroundDespite efforts to enhance the safety of the blood supply, transfusion-transmissible infections (TTIs) continue to pose a significant problem. This study determined the trends of TTIs among blood donors in a Regional Hospital in Ghana from 2017 to 2022.MethodsA retrospective analysis was conducted on the records of 6,339 blood donors to determine the presence of anti- human immunodeficiency virus 1/2 IgG/IgM, hepatitis B virus (HBV), anti-hepatitis C virus (HCV) IgG/IgM, and anti-Treponema pallidum IgG/IgM/IgA. Data were analyzed using STATA version 17.0. Both descriptive and inferential statistics were employed at a significance level of 0.05.ResultsOf the 6339 blood donors, 16.1% showed serological evidence of at least one TTI. The trend analysis showed that the prevalence rates of TTIs were 31.4% in 2017, 13.8% in 2018, 20.4% in 2019, decreased to 9.5% in 2020, 9.6% in 2021 and increased to 11.7% in 2022. TTIs were dominant among male blood donors compared to female blood donors. There was a significant association between HCV, Syphilis, and sex (aOR = 2.06; 95% CI [0.59-1.73]; P = .003) and (aOR = 2.28; 95% CI [0.15-0.69]; P < .001) respectively. Donors aged 20 to 29 were more likely to be infected with HBV (aOR = 1.96; 95%CI [1.28-2.99]; P = .002). Also, donors aged 40 to 49 years were more likely to be infected with HCV and Syphilis (aOR = 3.36; 95% CI [2.02-5.57]; P < .001) and (aOR = 3.79; 95% CI [2.45-5.87]; P < .001) respectively.ConclusionThe study identified a high overall prevalence of TTIs, highlighting the need to encourage female donor participation, raise awareness among young adults about safe practices, and implement targeted prevention strategies for males with a higher TTI prevalence.