PDF(Pubmed)
Abstract：
BACKGROUND: Perinatal brain injury may lead to later neurodevelopmental disorders, whose outcomes may vary due to neuroplasticity in young children. Recent neuroimaging studies have shown that the left parietotemporal area (which includes the left inferior parietal lobe) is associated with phonological awareness and decoding skills, which are essential skills for reading acquisition in children. However, the literature on the effect of perinatal cerebral injury on the development of phonological awareness or decoding ability in childhood is limited.
METHODS: We report the case of an 8-year-old boy who presented with reading difficulty following a perinatal injury in the parieto-temporal-occipital lobes. The patient was born at term and was treated for hypoglycemia and seizures during the neonatal period. Diffusion-weighted brain magnetic resonance imaging on postnatal day 4 revealed cortical and subcortical hyperintensities in the parieto-temporo-occipital lobe. At the age of 8 years, physical examination was unremarkable, aside from mild clumsiness. Despite occipital lobe injury, the patient had adequate visual acuity, normal eye movement, and no visual field defects. Full-scale intelligence quotient and verbal comprehension index on Wechsler Intelligence Scale for Children-Fourth Edition were 75 and 90, respectively. Further assessment revealed adequate recognition of Japanese Hiragana letters. However, he had significantly slower reading speed in the Hiragana reading test than control children. The phonological awareness test revealed significant errors (standard deviation +2.7) in the mora reversal task.
CONCLUSIONS: Patients with perinatal brain injuries in the parietotemporal area require attention and may benefit from additional reading instructions.
METHODS: We report the case of an 8-year-old boy who presented with reading difficulty following a perinatal injury in the parieto-temporal-occipital lobes. The patient was born at term and was treated for hypoglycemia and seizures during the neonatal period. Diffusion-weighted brain magnetic resonance imaging on postnatal day 4 revealed cortical and subcortical hyperintensities in the parieto-temporo-occipital lobe. At the age of 8 years, physical examination was unremarkable, aside from mild clumsiness. Despite occipital lobe injury, the patient had adequate visual acuity, normal eye movement, and no visual field defects. Full-scale intelligence quotient and verbal comprehension index on Wechsler Intelligence Scale for Children-Fourth Edition were 75 and 90, respectively. Further assessment revealed adequate recognition of Japanese Hiragana letters. However, he had significantly slower reading speed in the Hiragana reading test than control children. The phonological awareness test revealed significant errors (standard deviation +2.7) in the mora reversal task.
CONCLUSIONS: Patients with perinatal brain injuries in the parietotemporal area require attention and may benefit from additional reading instructions.
摘要：
背景：围产期脑损伤可能导致后期神经发育障碍，由于幼儿的神经可塑性，其结果可能会有所不同。最近的神经影像学研究表明，左顶颞区（包括左下顶叶）与语音意识和解码技能有关，这是儿童阅读习得的基本技能。然而,关于围产期脑损伤对儿童语音意识或解码能力发展的影响的文献有限。
方法：我们报告了一个8岁男孩的案例，该男孩在顶颞叶枕叶的围产期损伤后出现阅读困难。患者足月出生，在新生儿期接受低血糖和癫痫发作治疗。出生后第4天的扩散加权脑磁共振成像显示顶颞枕叶的皮质和皮质下高强度。在8岁的时候，体检并不显著，除了轻微的笨拙。尽管枕叶受伤，病人有足够的视力，正常的眼球运动,没有视野缺陷.韦氏儿童智力量表第四版的全面智商和言语理解指数分别为75和90。进一步评估显示，日本平假名字母得到了充分认可。然而,在平假名阅读测试中，他的阅读速度明显低于对照组儿童。语音意识测试显示，在mora逆转任务中存在重大错误（标准偏差2.7）。
结论：在顶颞区患有围产期脑损伤的患者需要注意，并且可能会从额外的阅读说明中受益。
方法：我们报告了一个8岁男孩的案例，该男孩在顶颞叶枕叶的围产期损伤后出现阅读困难。患者足月出生，在新生儿期接受低血糖和癫痫发作治疗。出生后第4天的扩散加权脑磁共振成像显示顶颞枕叶的皮质和皮质下高强度。在8岁的时候，体检并不显著，除了轻微的笨拙。尽管枕叶受伤，病人有足够的视力，正常的眼球运动,没有视野缺陷.韦氏儿童智力量表第四版的全面智商和言语理解指数分别为75和90。进一步评估显示，日本平假名字母得到了充分认可。然而,在平假名阅读测试中，他的阅读速度明显低于对照组儿童。语音意识测试显示，在mora逆转任务中存在重大错误（标准偏差2.7）。
结论：在顶颞区患有围产期脑损伤的患者需要注意，并且可能会从额外的阅读说明中受益。
