Abstract：
BACKGROUND: Campylobacter spp. is the leading cause of bacterial enteritis in industrialized countries, but the literature about its recurrence is scarce. The objective of this study is to analyze a case series of recurrent campylobacteriosis in adult and pediatric patients.
METHODS: During a two-year period, the demographic, clinical and microbiological data were collected retrospectively from patients who met the clinical criteria of recurrent Campylobacter spp. gastroenteritis. Enteropathogens were identified by a multiplex-PCR gastrointestinal pathogens panel. When Campylobacter spp. was detected, the stool sample was cultured in specific medium and tested for antibiotic susceptibility.
RESULTS: Twenty-four (2.03%) out of 1180 patients with Campylobacter spp. positive-PCR met the inclusion criteria. Thirteen patients suffered from underlying diseases, and 11 had no known risk factors but they were all pediatric patients. From the 24 patients were documented 70 episodes. One patient had two episodes of bacteremia. Coinfection/co-detection with other enteropathogens was found in 10 patients being Giardia intestinalis the most frequent. Twelve (22.6%) out of 53 isolates were resistant to macrolides. One patient had two isolates of multi-drug resistant C. coli, only susceptible to gentamicin.
CONCLUSIONS: The results suggest the presence of underlying diseases in most adult patients with recurrent Campylobacter spp. infections, particularly primary immunodeficiency. Most of the pediatric patients with recurrent campylobacteriosis lack of known risk factors. Concomitant detection with other enteropathogens was common. The resistance to macrolides was much higher as compared with previous reported rates.
METHODS: During a two-year period, the demographic, clinical and microbiological data were collected retrospectively from patients who met the clinical criteria of recurrent Campylobacter spp. gastroenteritis. Enteropathogens were identified by a multiplex-PCR gastrointestinal pathogens panel. When Campylobacter spp. was detected, the stool sample was cultured in specific medium and tested for antibiotic susceptibility.
RESULTS: Twenty-four (2.03%) out of 1180 patients with Campylobacter spp. positive-PCR met the inclusion criteria. Thirteen patients suffered from underlying diseases, and 11 had no known risk factors but they were all pediatric patients. From the 24 patients were documented 70 episodes. One patient had two episodes of bacteremia. Coinfection/co-detection with other enteropathogens was found in 10 patients being Giardia intestinalis the most frequent. Twelve (22.6%) out of 53 isolates were resistant to macrolides. One patient had two isolates of multi-drug resistant C. coli, only susceptible to gentamicin.
CONCLUSIONS: The results suggest the presence of underlying diseases in most adult patients with recurrent Campylobacter spp. infections, particularly primary immunodeficiency. Most of the pediatric patients with recurrent campylobacteriosis lack of known risk factors. Concomitant detection with other enteropathogens was common. The resistance to macrolides was much higher as compared with previous reported rates.
摘要：
背景：弯曲杆菌属。是工业化国家细菌性肠炎的主要原因，但是关于它复发的文献很少。这项研究的目的是分析成人和儿童患者中复发性弯曲杆菌病的病例系列。
方法：在两年期间，人口统计，回顾性收集了符合复发性弯曲杆菌临床标准的患者的临床和微生物学数据.胃肠炎.通过多重PCR胃肠道病原体小组鉴定肠病原体。当弯曲杆菌属。被检测到,粪便样本在特定培养基中培养，并测试抗生素敏感性。
结果：1180例弯曲杆菌患者中有24例（2.03%）。PCR阳性符合纳入标准.13名患者患有基础疾病，11例患者无已知危险因素,但均为儿科患者.从24名患者中记录了70次发作。一名患者有两次菌血症发作。在10例患者中发现了与其他肠病原体的共感染/共检测，这些患者是最常见的肠贾第鞭毛虫。53个分离株中有12个（22.6％）对大环内酯类药物具有抗性。一名患者有两株多重耐药大肠杆菌，只对庆大霉素敏感.
结论：结果表明，大多数患有复发性弯曲杆菌的成年患者存在潜在疾病。感染,特别是原发性免疫缺陷。大多数反复弯曲杆菌病的儿科患者缺乏已知的危险因素。与其他肠病原体同时检测是常见的。与以前报道的比率相比，对大环内酯的抗性要高得多。
方法：在两年期间，人口统计，回顾性收集了符合复发性弯曲杆菌临床标准的患者的临床和微生物学数据.胃肠炎.通过多重PCR胃肠道病原体小组鉴定肠病原体。当弯曲杆菌属。被检测到,粪便样本在特定培养基中培养，并测试抗生素敏感性。
结果：1180例弯曲杆菌患者中有24例（2.03%）。PCR阳性符合纳入标准.13名患者患有基础疾病，11例患者无已知危险因素,但均为儿科患者.从24名患者中记录了70次发作。一名患者有两次菌血症发作。在10例患者中发现了与其他肠病原体的共感染/共检测，这些患者是最常见的肠贾第鞭毛虫。53个分离株中有12个（22.6％）对大环内酯类药物具有抗性。一名患者有两株多重耐药大肠杆菌，只对庆大霉素敏感.
结论：结果表明，大多数患有复发性弯曲杆菌的成年患者存在潜在疾病。感染,特别是原发性免疫缺陷。大多数反复弯曲杆菌病的儿科患者缺乏已知的危险因素。与其他肠病原体同时检测是常见的。与以前报道的比率相比，对大环内酯的抗性要高得多。
