Abstract：
Ferroptosis is distinct from other apoptotic forms of programmed cell death and is characterized by the accumulation of iron and lipid peroxidation. Iron plays a crucial role in the oxidation of lipids via the Fenton reaction with oxygen. Hence, iron accumulation causes phospholipid peroxidation which induces ferroptosis. Moreover, detoxification by glutathione is disrupted during ferroptosis. A growing number of studies have implicated ferroptosis in nervous system disorders such as depression, neurodegenerative disease, stroke, traumatic brain injury, and sepsis-associated encephalopathy. This review summarizes the pathogenesis of ferroptosis and its relationship with various nervous system disorders.
摘要：
铁凋亡与程序性细胞死亡的其他凋亡形式不同，其特征在于铁和脂质过氧化的积累。铁通过与氧的Fenton反应在脂质的氧化中起关键作用。因此，铁的积累会导致磷脂过氧化，从而诱导铁凋亡。此外，谷胱甘肽的解毒作用在铁死亡过程中被破坏。越来越多的研究表明铁性凋亡与抑郁症等神经系统疾病有关，神经退行性疾病，中风,创伤性脑损伤,和脓毒症相关性脑病。本文就铁性凋亡的发病机制及其与各种神经系统疾病的关系作一综述。
