{Reference Type}: Journal Article
{Title}: The Role of Ferroptosis in Nervous System Disorders.
{Author}: Du L;Wu Y;Fan Z;Li Y;Guo X;Fang Z;Zhang X;
{Journal}: J Integr Neurosci
{Volume}: 22
{Issue}: 1
{Year}: Jan 2023 16
{Factor}: 1.664
{DOI}: 10.31083/j.jin2201019
{Abstract}: Ferroptosis is distinct from other apoptotic forms of programmed cell death and is characterized by the accumulation of iron and lipid peroxidation. Iron plays a crucial role in the oxidation of lipids via the Fenton reaction with oxygen. Hence, iron accumulation causes phospholipid peroxidation which induces ferroptosis. Moreover, detoxification by glutathione is disrupted during ferroptosis. A growing number of studies have implicated ferroptosis in nervous system disorders such as depression, neurodegenerative disease, stroke, traumatic brain injury, and sepsis-associated encephalopathy. This review summarizes the pathogenesis of ferroptosis and its relationship with various nervous system disorders.