%0 Journal Article
%T The Role of Ferroptosis in Nervous System Disorders.
%A Du L
%A Wu Y
%A Fan Z
%A Li Y
%A Guo X
%A Fang Z
%A Zhang X
%J J Integr Neurosci
%V 22
%N 1
%D Jan 2023 16
%M 36722234
%F 1.664
%R 10.31083/j.jin2201019
%X Ferroptosis is distinct from other apoptotic forms of programmed cell death and is characterized by the accumulation of iron and lipid peroxidation. Iron plays a crucial role in the oxidation of lipids via the Fenton reaction with oxygen. Hence, iron accumulation causes phospholipid peroxidation which induces ferroptosis. Moreover, detoxification by glutathione is disrupted during ferroptosis. A growing number of studies have implicated ferroptosis in nervous system disorders such as depression, neurodegenerative disease, stroke, traumatic brain injury, and sepsis-associated encephalopathy. This review summarizes the pathogenesis of ferroptosis and its relationship with various nervous system disorders.