糖脂代谢紊乱生物标志物的多组学研究进展.
关键词: 1,5-AG, 1,5-anhydroglucitol 2-AAA, 2-aminoadipic acid 2-DGE, two-dimensional gel electrophoresis ABCC8, ATP binding cassette subfamily C member 8 ADA, American Diabetes Association AhR, aromatic hydrocarbon receptor BA, bile acid BCAA, branched-chain amino acid BCKAs, branched chain keto acids Biomarkers CE, cholesterol ester CFL1, cofilin-1 CRP, C reactive protein CYP450, cytochrome P450 DAG, diacylglycerol DPP-4, dipeptyl peptidase 4 EASD, European Association for the Study of Diabetes FA, fatty acid FFA, free fatty acid FMT, fecal microbiota transplantation FTO, fat mass and obesity-associated GAS5, growth arrest-specific transcript 5 GC–MS/MS, gas chromatography-tandem mass spectrometry GLP-1, glucagon-like peptide 1 GLP-1R, glucagon-like peptide 1 receptor GSIS, glucose-stimulated insulin secretion GWAS, genome-wide association study Glycolipid metabolism disorder HGF, hepatocyte growth factor HMG-CoA, hydroxymethylglutaryl-coenzyme A HMGCR, 3-hydroxy-methylglutaryl coenzyme A reductase HPLC, high performance liquid chromatography HbA1C, glycylated hemoglobin IL-1ra, interleukin-1 receptor antagonist IMP, imidazole propionate IR, insulin resistance JNK, c-Jun-N-terminal-kinase KCNJ11, potassium inwardly rectifying channel subfamily J member 11 L-GPC, linoleoyl-glycerophosphocholine LC-MS/MS, liquid chromatography-tandem mass spectrometry LPC, lysophosphatidylcholine LPE, lysophosphatidylethanolamines LPS, lipopolysaccharide MAPK, mitogen-activated protein kinase MASP, mannose-binding lectin-associated serine protease 1 MATE1, multidrug and toxin extrusion protein 1 MDR1, multidrug resistance mutation 1 MGT, magnesium transporter MS, Mass Spectrometry Mechanism study Multi-omics NK, natural killer NMR, nuclear magnetic resonance OCT, organic cationic transporter OGTT, oral glucose tolerance test PC-PL, phosphatidylcholine-plasmalogen PE, phosphatidylethanolamines PNPLA3, patatin-like phospholipase domain-containing protein 3 PPAR, peroxisome proliferator-activated receptor PTBP1, polypyrimidine tract-binding protein 1 PTP, protein tyrosine phosphatase RNS, reactive nitrogen species ROS, reactive oxygen species SCFA, short-chain fatty acid SLC30A8, solute carrier family 30 member 8 SLC47A1, solute carrier family 47 member 1 SLC5A2, solute carrier family 5 member 2 SM, sphingomyelin SNP, single-nucleotide polymorphism SSPG, steady-state plasma glucose SUR1, sulfonylurea receptor 1 T2DM, type 2 diabetes mellitus TAG, triacylglycerol TCA, tricarboxylic acid TCF7L2, transcription factor 7-like 2 TF, transcription factor TMA, trimethylamine TMAO, trimethylamine oxide TNF-α, tumor necrosis factor alpha TOF-MS, time-of-flight mass spectrum TUG1, taurine upregulated gene 1 USP20, ubiquitin-specificpeptidase 20 WBC, white blood cell circRNA, circular RNA hADCS, human adipose-derived stem cells hsCRP, high-sensitivity C-reactive protein lnc-BATE1, brown adipose tissue enriched long non-coding RNA 1 lncRNA SHGL, lncRNA suppressor of hepatic gluconeogenesis and lipogenesis lncRNA, long non-coding RNA mRNA, messenger RNAs mTORC1, mechanistic target of rapamycin complex 1 miRNA, micro RNA ncRNA, non-coding RNA t-PA, tissue plasminogen activator α-HB, α-hydroxybutyrate
来 源:
DOI:10.1016/j.csbj.2022.10.030
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