未经证实:代谢异常可导致非酒精性脂肪性肝病(NAFLD)患者的肝纤维化,增加对肝细胞癌(HCC)的易感性。因此,我们的目的是在有和没有肝纤维化的患者中鉴定HCC的新型预测生物标志物。
UNASSIGNED:在我们的门诊中连续评估了1,234例推定代谢状况和NAFLD的患者。记录临床和生化数据,然后每年进行肝脏超声检查,持续5年,以检测HCC的发病。为了分析,首先根据HCC诊断对人群进行分组;然后根据时间0时是否存在肝纤维化对未发生HCC的人群进行进一步细分.
未经证实:5年内记录了16例HCC病例。在检测到HCC之前,我们的患者均未被诊断为肝硬化。与未发展为HCC的患者相比,那些在时间0有较高的肝转氨酶和纤维化评分(p<0.001)。此外,患者糖化血红蛋白水平升高,25-OH维生素D水平降低(p<0.05).有趣的是,肝纤维化评分较高、随后发展为HCC的患者在时间0时HDL-胆固醇(HDL-c)水平较低(p<0.001).此外,在基线时HDL-c较低的484例患者中,我们发现腰围,然后是维生素D和糖化血红蛋白水平,患肝癌的人有显著不同,无论肝纤维化(P<0.05)。
未经证实:本研究将HDL-c确定为预测NAFLD患者HCC的全新标志物。腰围增加和代谢途径紊乱是低HDL-c患者的其他诱发因素,强调研究胆固醇代谢并将临床方法与饮食方案和健康的生活方式相结合以预防HCC的重要性。
UNASSIGNED:内脏肥胖及其相关状况,比如慢性炎症和胰岛素抵抗,可能在非酒精性脂肪性肝病患者肝细胞癌的发展中起关键作用。我们为其发病机制提供了新的见解,阐明低水平的“好”高密度脂蛋白胆固醇的参与。我们建议将饮食方案和健康生活方式的建议纳入非酒精性脂肪性肝病的临床管理。目的是降低肝细胞癌的发病率。
UNASSIGNED: Dysmetabolic conditions could drive liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD), increasing susceptibility to hepatocellular carcinoma (HCC). We therefore aimed to identify novel predictive biomarkers of HCC in patients with and without liver fibrosis.
UNASSIGNED: A total of 1,234 patients with putative metabolic conditions and NAFLD were consecutively assessed in our outpatient clinic. Clinical and biochemical data were recorded, and then liver ultrasonography was performed annually for 5 years to detect HCC onset. For the analysis, the population was first divided according to HCC diagnosis; then a further subdivision of those who did not develop HCC was performed based on the presence or absence of liver fibrosis at time 0.
UNASSIGNED: Sixteen HCC cases were recorded in 5 years. None of our patients had been diagnosed with cirrhosis before HCC was detected. Compared to patients who did not develop HCC, those who did had higher liver transaminases and fibrosis scores at time 0 (p <0.001). In addition, they presented with increased glycated haemoglobin levels and lower 25-OH vitamin D levels (p <0.05). Intriguingly, patients with higher liver fibrosis scores who subsequently developed HCC had lower HDL-cholesterol (HDL-c) levels at time 0 (p <0.001). Furthermore, in the 484 patients presenting with lower HDL-c at baseline, we found that waist circumference, and then vitamin D and glycated haemoglobin levels, were significantly different in those who developed HCC, regardless of liver fibrosis (p <0.05).
UNASSIGNED: This study identifies HDL-c as a bona fide novel marker to predict HCC in patients with NAFLD. Increased waist circumference and deranged metabolic pathways represent additional predisposing factors among patients with low HDL-c, highlighting the importance of studying cholesterol metabolism and integrating clinical approaches with dietary regimens and a healthy lifestyle to prevent HCC.
UNASSIGNED: Visceral adiposity and its associated conditions, such as chronic inflammation and insulin resistance, may play a pivotal role in hepatocellular carcinoma development in patients with non-alcoholic fatty liver disease. We provide new insights on the underlying mechanisms of its pathogenesis, shedding light on the involvement of low levels of \"good\" HDL-cholesterol. We recommend integrating dietary regimens and advice on healthy lifestyles into the clinical management of non-alcoholic fatty liver disease, with the goal of reducing the incidence of hepatocellular carcinoma.