Abstract：
Monkeypox is a zoonotic disease, endemic in central and west African regions, and has re-emerged, currently causing an outbreak as of May 2022. In this systematic review, we aimed to characterize the current face of the disease, with a detailed categorization of mucocutaneous, as well as systemic symptoms of the disease. We searched four main online databases with the keywords \"monkeypox\" and \"Orthopoxvirus\". A total of 46 articles were included, with a cumulative number of 1984 confirmed cases. Patients were predominantly men who have sex with men, who were mostly in their 30s, with a history of unprotected sexual contact or international travel. Among mucocutaneous manifestations, anogenital lesions were the most commonly observed, followed by lesions on the limbs, face, trunk, and palms or soles. Among lesion types, vesiculopustular, pustular or pseudo-pustular, vesicular-umbilicated and papular lesions were the most common, mainly presenting asynchronously, with less than 10 lesions on each patient. Almost all patients also reported systemic manifestations, namely fever, lymphadenopathy, fatigue, myalgia, headaches, pharyngitis, and proctitis. Sexual contact is the main pathway of transmission in the current outbreak, with viral shedding in bodily fluids playing a key role. We\'ve compared these idiosyncratic findings of the new outbreak with previous outbreaks. We\'ve also gathered and categorized images from our included studies to make a \"clinical atlas\" for this \"new\" face of monkeypox, which can be of utmost importance for clinicians to be familiarized with, and have a clear picture of monkeypox for their differential diagnoses.
摘要：
猴痘是一种人畜共患疾病,中部和西部非洲地区的地方病，并重新出现，目前导致截至2022年5月的疫情爆发。在这次系统审查中，我们的目标是描述疾病的当前面貌，对皮肤粘膜进行了详细的分类，以及该疾病的全身症状。我们搜索了四个主要的在线数据库，关键字为“猴痘”和“正痘病毒”。共收录46篇文章,累计1984年确诊病例。患者主要是与男性发生性关系的男性，他们大多在30多岁，有无保护的性接触或国际旅行史。在皮肤粘膜表现中，肛门生殖器病变是最常见的，然后是四肢的病变,脸,树干,和手掌或鞋底。在病变类型中，膀胱脓疱，脓疱或假脓疱，泡状膜和丘疹性病变是最常见的，主要是异步呈现，每个患者的病变少于10个。几乎所有患者也报告了全身表现，即发烧,淋巴结病，疲劳,肌痛，头痛,咽炎,和直肠炎。性接触是本次疫情的主要传播途径,体液中的病毒脱落起着关键作用。我们已经将这些新爆发的特殊发现与以前的爆发进行了比较。我们还从我们纳入的研究中收集并分类了图像，为这个“新的”猴痘面孔制作了一个“临床地图集”，这对临床医生来说是最重要的，并对猴痘的鉴别诊断有清晰的了解。
