Atlas

图集
  • 文章类型: Journal Article
    在过去的二十年中,扩散张量成像(DTI)的使用取得了重大进展,特别是随着用于术前计划的关联束纤维束造影的发展。然而,投影束难以彼此区分,并且纤维束造影研究未能重建这些从/到脊髓的上升/下降途径。本研究提出了专门为投影束纤维束成像设计的感兴趣区域(ROI)图集。49名健康受试者被纳入这项前瞻性研究。使用相同的3TMRI扫描仪获取大脑DTI,有32个扩散方向。使用FSL软件包校正失真。使用前连合(AC)-后连合(PC)线在以下标志上绘制ROI:皮质脊髓束的金字塔,红髓核的中尾部分,脑桥网状核用于皮质网状束,小脑的上小脑和下小脑,分别,脊髓小脑前后束,背柱的皱褶和楔子核,和脊髓丘脑束的腹-后外侧核。使用DSIStudio软件使用确定性算法进行纤维跟踪。ROI坐标,根据AC-PC线,为每个管道给出。获得了每个管道的纤维束造影,允许三维渲染和跟踪指标之间的比较。本研究报告了用于每个投影道的纤维束造影的特定ROI的准确设计。为了区分脊髓水平的投影束,这可能是有用的工具。
    The use of diffusion tensor imaging (DTI) has seen significant development over the last two decades, in particular with the development of the tractography of association tracts for preoperative planning of surgery. However, projection tracts are difficult to differentiate from one another and tractography studies have failed to reconstruct these ascending/descending pathways from/to the spinal cord. The present study proposes an atlas of regions of interest (ROIs) designed specifically for projection tracts tractography. Forty-nine healthy subjects were included in this prospective study. Brain DTI was acquired using the same 3 T MRI scanner, with 32 diffusion directions. Distortions were corrected using the FSL software package. ROIs were drawn using the anterior commissure (AC)-posterior commissure (PC) line on the following landmarks: the pyramid for the corticospinal tract, the medio-caudal part of the red nucleus for the rubrospinal tract, the pontine reticular nucleus for corticoreticular tract, the superior and inferior cerebellar peduncles for, respectively, the anterior and posterior spinocerebellar tract, the gracilis and cuneatus nucleus for the dorsal columns, and the ventro-posterolateral nucleus for the spinothalamic tract. Fiber tracking was performed using a deterministic algorithm using DSI Studio software. ROI coordinates, according to AC-PC line, were given for each tract. Tractography was obtained for each tract, allowing tridimensional rendering and comparison of tracking metrics between tracts. The present study reports the accurate design of specific ROIs for tractography of each projection tract. This could be a useful tool in order to differentiate projection tracts at the spinal cord level.
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  • 文章类型: Journal Article
    复杂的神经生理学和形态学实验需要合适的动物模型进行研究。由于其巨大的尺寸,兔子是研究脊髓功能的最成功的模型之一。然而,要实现对特定脊柱区域的精确手术入路,需要彻底了解脊髓的细胞结构及其与椎骨的空间关系。脊髓的全面解剖神经化学图谱对于获得这种见解是无价的。虽然有些啮齿动物和灵长类动物存在这样的地图集,兔子不存在。我们为兔子开发了一种脊髓图谱来弥合这一差距。利用各种神经化学标记物,包括NeuN抗体,钙结合蛋白28kDa,parvalbumin,胆碱乙酰转移酶,一氧化氮合酶,和非磷酸化重链神经丝(SMI-32抗体)-我们提出了不同脊髓神经元群体的可视化,各种脊髓指标,每个脊柱节段的横向切片的立体定位图,以及一张空间地图,详细说明了脊髓和椎骨在其整个长度上的复杂关系。
    Complex neurophysiological and morphologic experiments require suitable animal models for investigation. The rabbit is one of the most successful models for studying spinal cord functions owing to its substantial size. However, achieving precise surgical access to specific spinal regions requires a thorough understanding of the spinal cord\'s cytoarchitectonic structure and its spatial relationship with the vertebrae. The comprehensive anatomo-neurochemical atlases of the spinal cord are invaluable for attaining such insight. While such atlases exist for some rodents and primates, none exist for rabbits. We have developed a spinal cord atlas for rabbits to bridge this gap. Utilizing various neurochemical markers-including antibodies to NeuN, calbindin 28 kDa, parvalbumin, choline acetyltransferase, nitric oxide synthase, and non-phosphorylated heavy-chain neurofilaments (SMI-32 antibody)-we present the visualization of diverse spinal neuronal populations, various spinal cord metrics, stereotaxic maps of transverse slices for each spinal segment, and a spatial map detailing the intricate relationship between the spinal cord and the vertebrae across its entire length.
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  • 文章类型: Journal Article
    呼吸系统疾病是全世界死亡和残疾的主要原因之一。小鼠通常用作人类呼吸道疾病的模型。自发小鼠的表型分析,先天性,继承,或与治疗相关的呼吸道异常需要研究者将呼吸系统的正常解剖特征与因疾病而改变的特征区分开来。许多出版物描述了正常呼吸道发育的各个方面,主要集中在气管和肺的形态发生。然而,提供详细的低和高倍率的单一参考,常规苏木精和伊红(H&E)染色切片的高分辨率图像不存在,描绘了整个发育中的小鼠呼吸系统的所有主要结构。该图集的目的是通过从H&E染色的组织切片的整个载玻片扫描中建立高分辨率彩色显微照片的简明参考来纠正这一缺陷。该地图集具有发育中的小鼠上下呼吸道的详细描述和注释良好的图像,强调胚胎天(E)9.0至18.5和主要的出生后早期事件。所选图像说明了关键发育阶段的主要结构和事件,因此应帮助研究人员确认小鼠胚胎的实际年龄并区分正常形态以及结构(细胞和器官)异常。
    Respiratory diseases are one of the leading causes of death and disability around the world. Mice are commonly used as models of human respiratory disease. Phenotypic analysis of mice with spontaneous, congenital, inherited, or treatment-related respiratory tract abnormalities requires investigators to discriminate normal anatomic features of the respiratory system from those that have been altered by disease. Many publications describe individual aspects of normal respiratory tract development, primarily focusing on morphogenesis of the trachea and lung. However, a single reference providing detailed low- and high-magnification, high-resolution images of routine hematoxylin and eosin (H&E)-stained sections depicting all major structures of the entire developing murine respiratory system does not exist. The purpose of this atlas is to correct this deficiency by establishing one concise reference of high-resolution color photomicrographs from whole-slide scans of H&E-stained tissue sections. The atlas has detailed descriptions and well-annotated images of the developing mouse upper and lower respiratory tracts emphasizing embryonic days (E) 9.0 to 18.5 and major early postnatal events. The selected images illustrate the main structures and events at key developmental stages and thus should help investigators both confirm the chronological age of mouse embryos and distinguish normal morphology as well as structural (cellular and organ) abnormalities.
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  • 文章类型: Journal Article
    背景:乳腺癌前哨淋巴结(SLN)的识别和评估对于优化患者管理很重要。这项研究的目的是开发交互式3D乳房SLN图谱,并对淋巴引流模式和肿瘤患病率进行统计分析。
    方法:共纳入861例术前淋巴显像和SPECT/CT的早期乳腺癌患者。使用贝叶斯推断计算淋巴引流和肿瘤患病率统计数据,非参数引导,和回归技术。对350例患者进行了SPECT/CT与参考患者CT的图像配准,和相对于参考CT变换的SLN位置。对参考CT进行分段以可视化骨骼和肌肉,和SLN分布与欧洲治疗放射学和肿瘤学学会(ESTRO)临床目标体积(CTV)相比。SLN图集和统计分析被集成到图形用户界面(GUI)中。
    结果:最常见的是直接淋巴引流到腋窝I级(前)结野(77.2%),其次是乳腺内结区(30.4%)。上外乳腺象限的肿瘤患病率最高(22.9%),其次是乳晕后区域(12.8%)。3D图谱有335名患者的765个SLN,ESTROCTV覆盖33.3-66.7%的腋窝SLN和25.4%的内乳SLN。
    结论:交互式3D图集有效地显示了大型患者队列的乳腺SLN分布和统计数据。该地图集可免费下载,是一种宝贵的教育资源,将来可用于指导治疗。
    BACKGROUND: The identification and assessment of sentinel lymph nodes (SLNs) in breast cancer is important for optimised patient management. The aim of this study was to develop an interactive 3D breast SLN atlas and to perform statistical analyses of lymphatic drainage patterns and tumour prevalence.
    METHODS: A total of 861 early-stage breast cancer patients who underwent preoperative lymphoscintigraphy and SPECT/CT were included. Lymphatic drainage and tumour prevalence statistics were computed using Bayesian inference, non-parametric bootstrapping, and regression techniques. Image registration of SPECT/CT to a reference patient CT was carried out on 350 patients, and SLN positions transformed relative to the reference CT. The reference CT was segmented to visualise bones and muscles, and SLN distributions compared with the European Society for Therapeutic Radiology and Oncology (ESTRO) clinical target volumes (CTVs). The SLN atlas and statistical analyses were integrated into a graphical user interface (GUI).
    RESULTS: Direct lymphatic drainage to the axilla level I (anterior) node field was most common (77.2%), followed by the internal mammary node field (30.4%). Tumour prevalence was highest in the upper outer breast quadrant (22.9%) followed by the retroareolar region (12.8%). The 3D atlas had 765 SLNs from 335 patients, with 33.3-66.7% of axillary SLNs and 25.4% of internal mammary SLNs covered by ESTRO CTVs.
    CONCLUSIONS: The interactive 3D atlas effectively displays breast SLN distribution and statistics for a large patient cohort. The atlas is freely available to download and is a valuable educational resource that could be used in future to guide treatment.
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  • 文章类型: Journal Article
    目的:设计并验证秘鲁食品的摄影图集,以评估6至12个月大儿童的食品消费量。
    方法:定量,描述性,描述性和横断面研究。根据其营养成分建立了12个食物组。该地图集旨在应用于母亲,父亲们,或6至12个月大的儿童的看护人。方法分为四个阶段:i)选择食物清单,来自秘鲁的区域食谱书籍进行了审查,然后对该年龄范围内儿童的母亲进行访谈,以最终选择食物清单;ii)食物的制备和称重,餐具用于建立家庭测量,并根据已建立的重量,用秘鲁食品的组成表计算宏观和微量营养素;iii)摄影会议的发展,使用了具有类似作品经验的专业摄影师;iv)专家验证,5位具有婴儿喂养经验的营养学家的参与。
    结果:建议的地图集包括57种食物,总共91张照片。根据食品类别和总体获得的含量效度系数为0.75(科恩的卡帕系数),这给了它可以接受的有效性和协议。
    结论:秘鲁用于婴儿喂养的食物部分的摄影图集是实用的,可靠,和文化上适当的视觉工具来帮助估计这个人口的食物消耗量,这将有助于估计食物摄入量。
    OBJECTIVE: Design and validation a photographic atlas of Peruvian foods to evaluate the food consumption of children from 6 to 12 months of age.
    METHODS: Quantitative, descriptive, and cross-sectional study. 12 food groups were established according to their nutrient content. The atlas is designed to be applied to mothers, fathers, or caregivers of children from 6 to 12 months of age. The methodology was divided into four stages: i) selection of the food list, regional recipe books from Peru were reviewed, then interviews with mothers of children in the age range were verified for the final selection of the food list; ii) preparation and weighing of food, utensils were used to establish home measurements and with the established weight the macro and micronutrients were calculated with tables of composition of Peruvian foods; iii) development of the photographic session, a professional photographer with previous experience in similar works was used; and iv) expert validation, with the participation of 5 nutritionists with experience in infant feeding.
    RESULTS: The proposed atlas includes 57 foods with a total of 91 photographs. The content validity coefficient according to food category and in total obtained an assessment of 0.75 (Cohen\'s kappa coefficient), which gives it acceptable validity and agreement.
    CONCLUSIONS: The photographic atlas of food portions for infant feeding in Peru is a practical, reliable, and culturally appropriate visual tool to help estimate the amount of food consumed by this population, which will facilitate the estimation of food intake.
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  • 文章类型: Journal Article
    背景:颈源性头痛很常见,被认为是上颈椎功能障碍的原因。地图集的活动性和位置已被确定为上颈椎功能障碍的原因。地图集的活动性完全受枕下肌的控制。斜头炎下肌收缩时对地图集有旋转作用。这项研究评估了干针电刺激引起的左斜头炎下肌收缩对寰枢关节中寰椎的位置和活动性的直接影响。方法:31名受试者参与本受试者内重复测量研究设计。每位受试者都接受了预先测量的颈部弯曲旋转测试,触诊图谱位置,用肌肉骨骼超声成像测量右斜头炎下肌的长度。在斜头炎下肌两次五秒钟的强直收缩后,重复了预先测量。结果:干预后分析显示右斜头肌下肌长度有明显变化。这种长度变化与介入后立即触诊的位置默认位置相关。结论:左斜头炎下肌的两个五秒强直收缩立即影响了寰枢关节中寰枢关节的位置。在我们的主题中,90%在左旋转中显示位置默认值,这与颈部屈曲旋转试验的变化有关。这项研究支持枕下肌张力可导致活动功能障碍的观点,因此,如宫颈源性头痛。
    Background: cervicogenic headaches are common and are believed to be the cause of dysfunction in the upper cervical spine. The mobility and the position of the atlas have been identified as a cause of upper cervical dysfunction. The mobility of the atlas is entirely under the control of the suboccipital muscles. The oblique capitis inferior muscle has a rotatory effect on the atlas when contracted. This study evaluated the immediate effects of a dry needling electrical stimulation-induced contraction of the left oblique capitis inferior muscle on the position and mobility of the atlas in the atlantoaxial joint. Methods: thirty-one subjects participated in this within-subject repeated measure study design. Each subject underwent a pre-measures neck flexion rotation test, palpation of the atlas position, and measurement of the length of the right oblique capitis inferior muscle with musculoskeletal ultrasound imaging. The pre-measures were repeated after two five-second tetanic contractions of the oblique capitis inferior muscle. Results: post-intervention analysis revealed significant changes in the length of the right oblique capitis inferior muscle. This length change correlated with the palpated positional default position immediately after the intervention. Conclusions: two five-second tetanic contractions of the left oblique capitis inferior muscle immediately affected the position of the atlas in the atlantoaxial joint. In our subjects, 90% displayed a positional default in the left rotation, and this was correlated with a change in the neck flexion rotation test. This study supports the notion that suboccipital muscle tonicity can result in mobility dysfunction and, thus, conditions such as cervicogenic headaches.
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  • 文章类型: Journal Article
    Ponticulusposticus(PP)是位于上关节突的后部和颈椎中的寰椎后弓的后外侧部分之间的骨性突起。这项研究的目的是验证意大利南部正畸前队列中不同类型PP的存在,以了解其与骨骼类别和成熟度的相关性。
    进行了病例对照回顾性研究,根据颈椎成熟方法,利用212张外侧远距X射线照片分析骨骼成熟度,角度错牙合的分类(I,II,或III),以及是否存在PP,无论是完全(c-PP)还是部分(p-PP)。总共分析了212张外侧头颅图。
    在72名男性患者中,67(93%)表现出PP,116(88%)为PP。卡方值为0.001,而Cramer'sV为0.270,表明年龄组与PP存在显著相关,和一个非常强大的整体协会。在41个完整的PP案例中,I类明显比II类和III类更为普遍。
    正畸医生在评估和治疗有或没有骨骼差异和牙齿异常的个体时,应仔细考虑PP。
    UNASSIGNED: Ponticulus posticus (PP) is a bony protrusion located between the posterior portion of the superior articular process and the posterolateral portion of a posterior arch of the atlas vertebrae in the cervical spine. The aim of this study is to verify the presence of different types of PP in a Southern Italian pre-orthodontic cohort to understand its correlation with skeletal class and maturity.
    UNASSIGNED: A case-control retrospective study was conducted, utilizing 212 latero-lateral telecranium radiographs to analyze skeletal maturity according to the cervical vertebral maturation method, the Angle\'s classification of malocclusion (I, II, or III), and the presence or absence of the PP, whether complete (c-PP) or partial (p-PP). A total of 212 lateral cephalograms were analyzed.
    UNASSIGNED: Of the 72 male patients, 67 (93%) exhibited PP, and 116 (88%) were PP. The chi-square value was 0.001, while Cramer\'s V was 0.270, indicating a significant correlation between age groups and PP presence, and a very strong association overall. Out of the 41 complete PP cases, class I was notably more prevalent than classes II and III.
    UNASSIGNED: Orthodontists should carefully consider PP when assessing and treating individuals with or without skeletal discrepancies and dental anomalies.
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  • 文章类型: Journal Article
    传统的视觉搜索任务不能直接解决注意力,它们对“设置大小”(显示项目的数量)的核心操纵引入了阻碍解释的刺激混淆。然而,替代方法尚未被广泛采用,也许反映了它们的复杂性,假设,或间接关注抽样。这里,一个新的程序,“注意位置和大小”(“ATLAS”)任务使用探针显示来跟踪注意位置,广度,搜索过程中的指导。尽管大多数探测器显示包含六个项目,参与者只报告了他们认为自己感觉最清楚的一个项目-索引注意力\“峰值\”。通过跨变量\'选择集\'采样峰值,搜索过程中注意窗口的大小和位置进行了分析。这些指数似乎与广泛的关注区分开来,发出了对出现的项目的关注信号,并随着时间的推移跟踪了不断发展的关注指导。ATLAS旨在区分五种关键搜索模式:串行无引导,顺序引导,在当地指导下,无指导地关注“团块”,以及有或没有指导的广泛平行关注。最初的调查仅使用了一组高度规则的刺激,但其更广泛的潜力应该被调查。
    Conventional visual search tasks do not address attention directly and their core manipulation of \'set size\' - the number of displayed items - introduces stimulus confounds that hinder interpretation. However, alternative approaches have not been widely adopted, perhaps reflecting their complexity, assumptions, or indirect attention-sampling. Here, a new procedure, the ATtention Location And Size (\'ATLAS\') task used probe displays to track attention\'s location, breadth, and guidance during search. Though most probe displays comprised six items, participants reported only the single item they judged themselves to have perceived most clearly - indexing the attention \'peak\'. By sampling peaks across variable \'choice sets\', the size and position of the attention window during search was profiled. These indices appeared to distinguish narrow- from broad attention, signalled attention to pairs of items where it arose and tracked evolving attention-guidance over time. ATLAS is designed to discriminate five key search modes: serial-unguided, sequential-guided, unguided attention to \'clumps\' with local guidance, and broad parallel-attention with or without guidance. This initial investigation used only an example set of highly regular stimuli, but its broader potential should be investigated.
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  • 文章类型: Journal Article
    这项研究的目的是提出面部及其解剖结构的形态分类类别,以及提出插图以支持地图集的开发,以促进成年巴西人的面部形态分析。这是一项描述性研究,基于对从巴西人口的代表性样本中获得的13种光人体测量面部比率(RFA)的频率和分布的分析。与面部高度和宽度相关的RFA,眼睛宽度,沟间距离,鼻子的长度和宽度,hiltrum脊的高度和宽度,嘴的厚度和宽度,上唇和下唇的厚度,和下巴高度进行了分析。该研究包括5.000名年龄在18至22岁之间的个体样本,在性别之间均匀分布。使用Shapiro-Wilk检验评估数据正常性,当p>0.05时,将它们视为参数。对于显示正态分布的RFA,平均值±1.5标准偏差(SD)用于将面部测量分类为常规,低于平均水平,或高于平均水平。基于数据的中位数和第10和第90百分位数分析非参数RFA。根据确定的平均虹膜直径,这被认为是最稳定的面部测量,所描述的RFA的值被转换为以厘米为单位的数字刻度,允许说明女性和男性的面孔。这样,可以对面部解剖结构进行分类,因此,可视化巴西成年人口的面部形态模式。
    The objective of this study was to propose categories of morphological classification for the face and its anatomical structures, as well as to propose illustrations to support the development of an atlas that facilitates facial morphological analysis of adult Brazilians. It was a descriptive study based on the analysis of the frequency and distribution of 13 photoanthropometric facial ratios (RFAs) obtained from a representative sample of the Brazilian population. RFAs related to facial height and width, eye width, intercanthal distance, nose length and width, philtrum ridge height and width, mouth thickness and width, upper and lower lip thickness, and chin height were analyzed. The study included a sample of 5.000 individuals aged between 18 and 22 years, evenly distributed between genders. Data normality was assessed using the Shapiro-Wilk test, considering them as parametric when p > 0.05. For the RFAs that showed normal distribution, mean ± 1.5 standard deviations (SD) were used to categorize facial measurements as regular, below average, or above average. Non-parametric RFAs were analyzed based on the median and 10th and 90th percentiles of the data. Based on the established average iris diameter, which is considered the most stable facial measurement, the values of the described RFAs were converted to a numerical scale in centimeters, allowing for the illustration of female and male faces. In this way, it was possible to categorize the facial anatomical structures and, consequently, visualize the facial morphological pattern of the adult Brazilian population.
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  • 文章类型: Journal Article
    技术改进为牙科带来了重大创新,并扩大了牙科护理工具和技术的范围。在过去20年中广泛研究的一项技术发展是使用近红外透射照明(NIRT)成像来诊断龋齿。本文旨在介绍一个全面的NIRT图像集合,旨在作为常规牙科检查的参考工具,牙科研究,教学活动,和法医牙科学。该集合呈现了成对的临床和NIRT图像,分类如下:(a)健康的牙齿,(b)龋齿,(c)修复的牙齿,(d)釉质缺陷,和(e)不同的发现。该地图集可能是牙科界的宝贵工具,因为它被设计为NIRT说明牙齿特征的识别指南。
    Technological improvements have introduced significant innovations in dentistry and broadened the array of tools and techniques in dental care. One technological development that has been widely researched over the past 20 years is the use of Near-Infrared Transillumination (NIRT) imaging for the diagnosis of dental caries. This paper aims to introduce a comprehensive collection of NIRT images, intended as a reference tool for routine dental examinations, dental research, pedagogical activities, and forensic odontology. The collection presents pairwise clinical and NIRT images categorized as follows: (a) healthy teeth, (b) carious teeth, (c) restored teeth, (d) enamel defects, and (e) diverse findings. This atlas could be a valuable tool for the dental community as it is designed as an identification guide of NIRT illustrated dental features.
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