Abstract：
Smooth muscle cells (SMCs) are the major cell type of the aortic wall and play a pivotal role in the pathophysiology of thoracic aortic aneurysms (TAAs). TAAs occur in a region-specific manner with the proximal region being a common location. In this region, SMCs are derived embryonically from either the cardiac neural crest or the second heart field. These cells of distinct origins reside in specific locations and exhibit different biological behaviors in the complex mechanism of TAAs. The purpose of this review is to enhance understanding of the embryonic heterogeneity of SMCs in the proximal thoracic aorta and their functions in TAAs.
摘要：
平滑肌细胞（SMC）是主动脉壁的主要细胞类型，在胸主动脉瘤（TAAs）的病理生理中起关键作用。TAA以区域特异性方式发生,其中近侧区域是共同位置。在这个地区,SMC是胚胎地来源于心脏神经c或第二心脏区域。这些不同来源的细胞位于特定位置，并在TAA的复杂机制中表现出不同的生物学行为。这篇综述的目的是加深对胸主动脉近端SMC的胚胎异质性及其在TAA中的功能的理解。
