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Abstract：
Aortic aneurysm is common, accounting for 1-2% of all deaths in industrialized countries. Early theories of the causes of human aneurysm mostly focused on inherited or acquired defects in components of the extracellular matrix in the aorta. Although several mutations in the genes encoding extracellular matrix proteins have been recognized, more recent discoveries have shown important perturbations in cytokine signalling cascades and intracellular components of the smooth muscle contractile apparatus. The modelling of single-gene heritable aneurysm disorders in mice has shown unexpected involvement of the transforming growth factor-β cytokine pathway in aortic aneurysm, highlighting the potential for new therapeutic strategies.
摘要：
主动脉瘤很常见，占工业化国家所有死亡人数的1-2%。人类动脉瘤原因的早期理论主要集中在主动脉细胞外基质成分的遗传或获得性缺陷上。尽管已经认识到编码细胞外基质蛋白的基因中的一些突变,最近的发现显示了细胞因子信号级联和平滑肌收缩装置的细胞内成分的重要扰动。小鼠单基因遗传性动脉瘤疾病的模型显示，主动脉瘤中转化生长因子-β细胞因子途径的意外参与，强调新的治疗策略的潜力。
