iPSC 衍生的马凡氏综合征血管模型鉴定了平滑肌细胞死亡的关键介质。
Mesh : Aortic Aneurysm / metabolism pathology Apoptosis Fibrillin-1 / metabolism Gene Expression Regulation Humans Induced Pluripotent Stem Cells / metabolism pathology Kruppel-Like Factor 4 Kruppel-Like Transcription Factors / metabolism Marfan Syndrome / metabolism pathology Models, Biological Muscle, Smooth, Vascular / metabolism pathology Signal Transduction Transforming Growth Factor beta / metabolism p38 Mitogen-Activated Protein Kinases / metabolism
来 源:
DOI:10.1038/ng.3723
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