PTP1B 抑制通过调节 OPA1 稳态改善线粒体动力学以缓解钙化性主动脉瓣疾病。
关键词: CAVD, calcific aortic valve disease HFD, high-fat diet L-OPA1, long form of OPA1 OPA1, optic atrophy 1 PTP1B, protein tyrosine phosphatase 1B S-OPA1, short form of OPA1 TGFβ, transforming growth factor β VIC, valvular interstitial cell calcific aortic valve disease mitochondrial biogenesis optic atrophy 1 protein tyrosine phosphatase 1B valvular interstitial cells β-GA, β-glycerophosphate acid CAVD, calcific aortic valve disease HFD, high-fat diet L-OPA1, long form of OPA1 OPA1, optic atrophy 1 PTP1B, protein tyrosine phosphatase 1B S-OPA1, short form of OPA1 TGFβ, transforming growth factor β VIC, valvular interstitial cell calcific aortic valve disease mitochondrial biogenesis optic atrophy 1 protein tyrosine phosphatase 1B valvular interstitial cells β-GA, β-glycerophosphate acid
来 源:
DOI:10.1016/j.jacbts.2022.03.002
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