关键词： CAVD, calcific aortic valve disease HFD, high-fat diet L-OPA1, long form of OPA1 OPA1, optic atrophy 1 PTP1B, protein tyrosine phosphatase 1B S-OPA1, short form of OPA1 TGFβ, transforming growth factor β VIC, valvular interstitial cell calcific aortic valve disease mitochondrial biogenesis optic atrophy 1 protein tyrosine phosphatase 1B valvular interstitial cells β-GA, β-glycerophosphate acid CAVD, calcific aortic valve disease HFD, high-fat diet L-OPA1, long form of OPA1 OPA1, optic atrophy 1 PTP1B, protein tyrosine phosphatase 1B S-OPA1, short form of OPA1 TGFβ, transforming growth factor β VIC, valvular interstitial cell calcific aortic valve disease mitochondrial biogenesis optic atrophy 1 protein tyrosine phosphatase 1B valvular interstitial cells β-GA, β-glycerophosphate acid

来  源：   DOI：10.1016/j.jacbts.2022.03.002   PDF(Pubmed)

Abstract：
There are currently no pharmacological therapies for calcific aortic valve disease (CAVD). Here, we evaluated the role of protein tyrosine phosphatase 1B (PTP1B) inhibition in CAVD. Up-regulation of PTP1B was critically involved in calcified human aortic valve, and PTP1B inhibition had beneficial effects in preventing fibrocalcific response in valvular interstitial cells and LDLR-/- mice. In addition, we reported a novel function of PTP1B in regulating mitochondrial homeostasis by interacting with the OPA1 isoform transition in valvular interstitial cell osteogenesis. Thus, these findings have identified PTP1B as a potential target for preventing aortic valve calcification in patients with CAVD.
摘要：
目前没有用于钙化性主动脉瓣疾病(CAVD)的药物疗法。这里,我们评估了蛋白酪氨酸磷酸酶1B（PTP1B）抑制在CAVD中的作用。PTP1B的上调与钙化的人主动脉瓣密切相关，和PTP1B抑制在阻止瓣膜间质细胞和LDLR-/-小鼠的纤维钙化反应方面具有有益作用。此外,我们报道了PTP1B在瓣膜间质细胞成骨过程中通过与OPA1同工型转变相互作用调节线粒体稳态的新功能.因此，这些发现确定PTP1B是CAVD患者预防主动脉瓣钙化的潜在靶点.
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